Dysregulated Neurovascular Control Underlies Declining Microvascular Functionality in People With Non-alcoholic Fatty Liver Disease (NAFLD) at Risk of Liver Fibrosis
| العنوان: | Dysregulated Neurovascular Control Underlies Declining Microvascular Functionality in People With Non-alcoholic Fatty Liver Disease (NAFLD) at Risk of Liver Fibrosis |
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| المؤلفون: | Geraldine F. Clough, Christopher D. Byrne, Marjola Thanaj, Andrew J. Chipperfield, Eleonora Scorletti, Philip C. Calder |
| المصدر: | Frontiers in Physiology Frontiers in Physiology, Vol 11 (2020) |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | skin, medicine.medical_specialty, Physiology, microcirculation, Hemodynamics, 030204 cardiovascular system & hematology, non-linear complexity analysis, Gastroenterology, lcsh:Physiology, Microcirculation, 03 medical and health sciences, 0302 clinical medicine, NAFLD, Physiology (medical), Internal medicine, medicine, blood flow, Respiratory system, Reactive hyperemia, Original Research, liver fibrosis, sympathetic nervous system, lcsh:QP1-981, business.industry, Fatty liver, Type 2 Diabetes Mellitus, Neurovascular bundle, medicine.disease, Dilator, flow-motion, business, 030217 neurology & neurosurgery |
| الوصف: | Background/Aims: Increasing evidence shows that non-alcoholic fatty liver disease (NAFLD) is associated with dysregulation of microvascular perfusion independently of established cardio-metabolic risk factors. We investigated whether hepatic manifestations of NAFLD such as liver fibrosis and liver fat are associated with microvascular hemodynamics through dysregulation of neurovascular control. Methods: Microvascular dilator (post-occlusive reactive hyperemia) and sympathetically mediated constrictor (deep inspiratory breath-hold) responses were measured at the forearm and finger, respectively, using laser Doppler fluximetry. Non-linear complexity-based analysis was used to assess the information content and variability of the resting blood flux (BF) signals, attributable to oscillatory flow-motion activity, and over multiple sampling frequencies. Results: Measurements were made in 189 adults (113 men) with NAFLD, with (n = 65) and without (n = 124) type 2 diabetes mellitus (T2DM), age = 50.9 ± 11.7 years (mean ± SD). Microvascular dilator and constrictor capacity were both negatively associated with age (r = −0.178, p = 0.014, and r = −0.201, p = 0.007, respectively) and enhanced liver fibrosis (ELF) score (r = −0.155, p = 0.038 and r = −0.418, p < 0.0001, respectively). There was no association with measures of liver fat, obesity or T2DM. Lempel-Ziv complexity (LZC) and sample entropy (SE) of the BF signal measured at the two skin sites were associated negatively with age (p < 0.01 and p < 0.001) and positively with ELF score (p < 0.05 and p < 0.0001). In individuals with an ELF score ≥7.8 the influence of both neurogenic and respiratory flow-motion activity on LZC was up-rated (p < 0.0001). Conclusion: Altered microvascular network functionality occurs in adults with NAFLD suggesting a mechanistic role for dysregulated neurovascular control in individuals at risk of severe liver fibrosis. |
| وصف الملف: | text |
| تدمد: | 1664-042X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a19d3b0210367bc3afeff98d61e592dTest https://doi.org/10.3389/fphys.2020.00551Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a19d3b0210367bc3afeff98d61e592d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664042X |
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