Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis
| العنوان: | Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis |
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| المؤلفون: | Andréa Teixeira de Carvalho, Danyelle Romana Alves Rios, Luci Maria Sant'Ana Dusse, Wander Valadares de Oliveira Júnior, Olindo Assis Martins-Filho, Melina de Barros Pinheiro, Ana Cristina Simões e Silva, Karina Braga Gomes |
| المصدر: | Disease Markers, Vol 2017 (2017) Disease Markers |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Article Subject, medicine.medical_treatment, Clinical Biochemistry, Disease, 030204 cardiovascular system & hematology, Gastroenterology, End stage renal disease, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, Internal medicine, Genetics, medicine, Humans, Stage (cooking), Molecular Biology, lcsh:R5-920, business.industry, Biochemistry (medical), Interleukin, Thrombosis, General Medicine, Middle Aged, medicine.disease, Surgery, 030104 developmental biology, Cytokine, Cytokines, Kidney Failure, Chronic, Female, Hemodialysis, Complication, business, lcsh:Medicine (General), Biomarkers, Research Article |
| الوصف: | Hemodialysis is a modality of blood filtration in which accumulated toxins and water are removed from the body. This treatment is indicated for patients at the end stage of renal disease. Vascular access complications are responsible for 20–25% of all hospitalizations in dialyzed patients. The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible, which is vital for the patient. The aim of this study was to investigate inflammatory profile in patients undergoing hemodialysis as well as the association between these alterations and vascular access thrombosis. A total of 195 patients undergoing hemodialysis have been evaluated; of which, 149 patients had not experienced vascular access thrombosis (group I) and 46 patients had previously presented this complication (group II). Plasma levels of cytokines including interleukin (IL-) 2, IL-4, IL-5, IL-10, TNF-α, and IFN-γwere measured by cytometric bead array. Our results showed that patients with previous thrombotic events (group II) had higher levels of the IL-2, IL-4, IL-5, and IFN-γwhen compared to those in group I. Furthermore, a different cytokine signature was detected in dialyzed patients according to previous occurrences or not of thrombotic events, suggesting that elevated levels of T-helper 1 and T-helper 2 cytokines might, at least in part, contribute to this complication. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1875-8630 0278-0240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399fb88bf2fc7dfbf71fd70cf8ad0375Test https://doaj.org/article/47250f57dc7547539100ab2d00d2f3bbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....399fb88bf2fc7dfbf71fd70cf8ad0375 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758630 02780240 |
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