A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk
| العنوان: | A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk |
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| المؤلفون: | Mélanie Deschasaux, Nathalie Druesne-Pecollo, Jean-Claude Souberbielle, Pilar Galan, Emmanuelle Kesse-Guyot, Sigrid Le Clerc, Angela Sutton, Nathalie Charnaux, Khaled Ezzedine, Paule Latino-Martel, Mathilde Touvier, Serge Hercberg |
| المساهمون: | ProdInra, Migration, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Jean Verdier [AP-HP], Public Health Department, Laboratoire génomique, bioinformatique et applications (GBA), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Dermatology Department, Habib Thameur Hospital, French Research Institute for Public Health (IRESP) [AAR201206], Cancéropôle Ile-de-France, Ile-de-France Region (PhD grant), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Physiology Department, CHU Necker - Enfants Malades [AP-HP]-Inserm U845, Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Jean Verdier [Bondy], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Département de Santé Publique, Hôpital Avicenne, Assistance Publique - Hôpitaux de Paris (AP-HP), Service de dermatologie Hôpital Saint-André Bordeaux, CHU Bordeaux [Bordeaux], Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Inserm U845, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Deschasaux-Tanguy, Mélanie, Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée |
| المصدر: | IARC's 50th Anniversary IARC's 50th Anniversary, Jun 2016, Lyon, France., 518 p., 2016, IARC's 50th Anniversary "Cancer: Occurrence, Causes, Prevention". Abstracts British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2016, 115 (2), pp.305-314. ⟨10.1017/S0007114515004353⟩ IARC's 50th Anniversary, Jun 2016, Lyon, France. 518 p., 2016, IARC's 50th Anniversary "Cancer: Occurrence, Causes, Prevention". Abstracts British Journal of Nutrition, 2016, 115 (2), pp.305-314. ⟨10.1017/S0007114515004353⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, 25(OH)2D 1, Medicine (miscellaneous), Parathyroid hormone, Nested case–control studies, Calcitriol receptor, Gastroenterology, gc-globulin or group-specific component, MAF minor allele frequency, Placebos, Prostate cancer, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, CaSR Ca-sensing receptor, 25-dihydroxyvitamin D3 24-hydroxylase, Prospective Studies, Vitamin D, Prospective cohort study, 25-dihydroxyvitamin D, ComputingMilieux_MISCELLANEOUS, Nutrition and Dietetics, GC vitamin D-binding globulin, Middle Aged, 3. Good health, 030220 oncology & carcinogenesis, Cohort, 25(OH)D 25-hydroxyvitamin D, Vitamin, Adult, medicine.medical_specialty, Genotype, SU.VI.MAX Supplémentation en Vitamines et Minéraux Antioxydants, SNP, 25-Hydroxyvitamin D, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Double-Blind Method, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, Vitamin D and neurology, medicine, Humans, RXR retinoid X receptor, PTH parathyroid hormone, Aged, Case-control study, Prostatic Neoplasms, VDR vitamin D receptor, Prostate cancer risk, medicine.disease, CYP24A1 1, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, Endocrinology, Retinoid X Receptors, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Receptors, Calcitriol, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| الوصف: | National audience; Purpose: Mechanistic hypotheses suggest that vitamin D may be involved in prostate carcinogenesis through various effects on differentiation, apoptosis, and cell proliferation. Plasma parathyroid hormone (PTH) concentration, closely related to vitamin D metabolism may also play a role in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. Methods: A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort were included in a nested case–control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from plasma samples obtained at baseline. SNPs of selected vitamin D-related genes (VDR BsmI, FokI and Cdx2, CYP24A1 rs4809958, GC rs4588 and rs7041, RXR rs7861779 and rs12004589, CaSR rs1801725 and rs4678174) were determined with TaqMan assay. Conditional logistic regression models were computed. Results: Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (OR Q4 vs. Q1=0.30 (0.12-0.77); P-trend=0.007). PTH concentration was not associated with prostate cancer risk (P-trend=0.4) neither did the studied vitamin D-related gene polymorphisms. Conclusions: In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0007-1145 1475-2662 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3882c2eeac96f0f59757319f8e41a5c9Test https://hal.inrae.fr/hal-02741787Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3882c2eeac96f0f59757319f8e41a5c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00071145 14752662 |
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