Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy
| العنوان: | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
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| المؤلفون: | André C. Knulst, Mark A. Blankestijn, Henny G. Otten, Thuy My Le, Rob J.B. Klemans, Edward F. Knol, Heike Röckmann |
| المصدر: | Clinical and Translational Allergy, 7(1). BioMed Central Clinical and Translational Allergy, Vol 7, Iss 1, Pp 1-8 (2017) Clinical and Translational Allergy |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Intoxicative inhalant, Allergy, Immunology, Adult population, Storage proteins, 03 medical and health sciences, 0302 clinical medicine, Food allergy, medicine, Storage protein, Immunology and Allergy, PR-10, Sensitization, chemistry.chemical_classification, Food protein, business.industry, Research, RC581-607, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Specific IgE, 030228 respiratory system, chemistry, Concomitant, Immunologic diseases. Allergy, ImmunoCAP ISAC, business |
| الوصف: | Background The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results A total of 305 patients were selected, aged 16–79 years (median 32 years). Sensitization to one or more PR-10 proteins was most frequent (74% of all subjects), followed by 35% to storage protein and 15% to nsLTPs. Within the PR-10 family, subjects were most often sensitized to Bet v 1 (73% of 305), Cor a 1.04 (72%) and Mal d 1 (68%). Sensitization to PR-10s from soy, celery and kiwi occurred distinctively less often ( 70%). Subjects sensitized to these ‘less common PR-10 proteins’ were sensitized to more food and inhalant components on the ISAC, compared to subjects sensitized to ‘common PR-10 proteins’ (median 22 vs 13 out of 112, p |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 2045-7022 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38626657f2e7528f4e2539f07fb750fcTest https://dspace.library.uu.nl/handle/1874/357650Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....38626657f2e7528f4e2539f07fb750fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457022 |
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