Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis
| العنوان: | Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis |
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| المؤلفون: | Torben A Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes, Tobias Frisch, Tim Kacprowski, Richard Reynolds, Mark Burton, Maria L. Elkjaer |
| المصدر: | Acta Neuropathologica Communications Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019) Elkjaer, M L, Frisch, T, Reynolds, R, Kacprowski, T, Burton, M, Kruse, T A, Thomassen, M, Baumbach, J & Illes, Z 2019, ' Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis ', Acta Neuropathologica Communications, vol. 7, 205 . https://doi.org/10.1186/s40478-019-0855-7Test |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Immunoglobulin gene, Pathology, medicine.medical_specialty, Context (language use), Biology, lcsh:RC346-429, Pathology and Forensic Medicine, Multiple sclerosis, Lesion, White matter, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Gene expression, medicine, Humans, TGF-beta, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, 0303 health sciences, Microglia, Sequence Analysis, RNA, Research, Gene Expression Profiling, Receptor, Transforming Growth Factor-beta Type II, Brain, High-Throughput Nucleotide Sequencing, Multiple Sclerosis, Chronic Progressive, medicine.disease, White Matter, ddc, 3. Good health, CD26/DPP4, Next-generation RNA sequencing, medicine.anatomical_structure, Human brain lesions, Immunohistochemistry, Secondary progressive, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery |
| الوصف: | To identify pathogenetic markers and potential drivers of different lesion types in the white matter (WM) of patients with progressive multiple sclerosis (PMS), we sequenced RNA from 73 different WM areas. Compared to 25 WM controls, 6713 out of 18,609 genes were significantly differentially expressed in MS tissues (FDR n = 2213), remyelinating lesions had the highest gene expression levels, and the most different molecular map from chronic active lesions. This may suggest that these two lesion types represent two ends of the spectrum of lesion evolution in PMS. The profound changes in chronic active lesions, the predominance of synaptic/neural/axonal signatures coupled with minor inflammation may indicate end-stage irreversible molecular events responsible for this less treatable phase. |
| وصف الملف: | application/pdf |
| تدمد: | 2051-5960 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3702a19d31b202097e87699320578a6eTest https://doi.org/10.1186/s40478-019-0855-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3702a19d31b202097e87699320578a6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20515960 |
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