Costs of clinical trials with anticancer biological agents in an Oncologic Italian Cancer Center using the activity-based costing methodology
| العنوان: | Costs of clinical trials with anticancer biological agents in an Oncologic Italian Cancer Center using the activity-based costing methodology |
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| المؤلفون: | Sandro Pignata, Antonio Nardone, Giacomo Pascarella, Antonella Petrillo, Paolo A. Ascierto, Nicola Maurea, Francesco Perrone, Alessandro Morabito, Agnese Montanino, Roberta D’Aniello, Gianfranco De Feo, Secondo Lastoria, Gerardo Botti, Laura Arenare, Marcello Curvietto, Ernesta Cavalcanti, Piera Maiolino, Arturo Capasso, Maria Triassi, Francesca Laudato |
| المساهمون: | Pascarella, Giacomo, Capasso, Arturo, Nardone, Antonio, Triassi, Maria, Pignata, Sandro, Arenare, Laura, Ascierto, Paolo, Curvietto, Marcello, Maiolino, Piera, D'Aniello, Roberta, Montanino, Agnese, Laudato, Francesca, De Feo, Gianfranco, Botti, Gerardo, Perrone, Francesco, Petrillo, Antonella, Cavalcanti, Ernesta, Lastoria, Secondo, Maurea, Nicola, Morabito, Alessandro |
| المصدر: | PLoS ONE, Vol 14, Iss 1, p e0210330 (2019) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Melanomas, Total cost, Cancer Treatment, Antineoplastic Agents, Immunological, 0302 clinical medicine, Neoplasms, Health care, Medicine and Health Sciences, Multicenter Studies as Topic, Medicine, 030212 general & internal medicine, Clinical Trials (Cancer Treatment), Activity-based costing, health care economics and organizations, Randomized Controlled Trials as Topic, Multidisciplinary, Health Care Costs, Anticancer Biological, Phase III clinical investigation, Italy, Oncology, Female, Oncology Agents, Research Article, medicine.medical_specialty, Drug Research and Development, Science, Immunology, MEDLINE, Antineoplastic Agents, Audit, Research and Analysis Methods, Drug Costs, 03 medical and health sciences, Antibody Therapy, Diagnostic Medicine, Humans, Clinical Trials, Pharmacology, business.industry, Cancers and Neoplasms, Biology and Life Sciences, Cancer, medicine.disease, Clinical trial, Clinical Trials, Phase III as Topic, Family medicine, 030221 ophthalmology & optometry, Clinical Immunology, Clinical Medicine, business |
| الوصف: | AimThe aim of the present study was to assess the estimated "per patient" total cost for a single Oncologic Italian Cancer Center participating in a multicenter clinical trial with new anticancer biological agents using the activity-based costing (ABC) methodology.MethodologyNine randomized phase 3 clinical trials employing biological agents at the National Cancer Institute of Napoli, Italy, were analyzed to indentify "per patient" costs of each trial, according to the ABC methodology. The average consumption of resources for a patient completing the entire planned treatment was estimated for each trial. Through interviews of the personnel (doctors, nurses and technicians) and by analyses of the clinical trials protocols, the main activities of the 9 clinical trials were identified and, for each trial, the complete health care pathway of the patients and the treatment programmes were minutely reconstructed. Drug costs were not included because provided by Sponsors.Principal findingsThe average costs of the pre-study, treatment, monitoring, follow-up, audit, and administrative activities accounted for 2.357, 4.783, 700, 372, 1.263, and 9 Euro, respectively. The average total cost estimated for all "per patient" activities, including overhead costs, was 11.379 Euro. Staff costs accounted for € 5.988, while costs of diagnostic test accounted for 3.494 Euro. Clinical trials with immunotherapeutic drugs accounted for higher costs (+601 Euro as oncological staff costs, +1.318 Euro as intermediate services cost and +384 Euro as overheads).ConclusionsThe average total cost estimated for all "per patient" activities of a clinical trial with new anticancer biological agents was 11.379 Euro using the ABC methodology. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c668cea8590fc7a505541b0b4acbd0Test https://doaj.org/article/56b60e557d7249d98acd2f419d2dfc17Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36c668cea8590fc7a505541b0b4acbd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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