The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors
| العنوان: | The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors |
|---|---|
| المؤلفون: | Sheng Jin, Jing Dai, Yuming Wu, Xu Teng |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aging, Receptors, Cell Surface, Transferrin receptor, Review Article, Protective Agents, Antiviral Agents, Biochemistry, Cell surface receptor, Neuropilin 1, Animals, Humans, Medicine, Hydrogen Sulfide, Receptor, QH573-671, SARS-CoV-2, business.industry, Cell Biology, General Medicine, Entry into host, Pathophysiology, Organ Specificity, Immunology, Cytology, business |
| الوصف: | The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H2S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H2S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H2S levels. Considering that the beneficial role of H2S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H2S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells. |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a0388ca7e1e28c904d503910116ce5Test https://doi.org/10.1155/2021/7866992Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36a0388ca7e1e28c904d503910116ce5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
|---|