Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes
| العنوان: | Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes |
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| المؤلفون: | Kim C. Donaghue, Alicia J. Jenkins, Tien Yin Wong, Sophie Rogers, Ning Cheung, Gabriella Tikellis |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Retinal Vessels - Physiopathology, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Arterioles - Physiopathology, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Ophthalmology, Diabetes mellitus, Internal Medicine, medicine, Humans, Prospective Studies, Fluorescein Angiography, Pathophysiology/Complications, Child, Prospective cohort study, Advanced and Specialized Nursing, Type 1 diabetes, Diabetic Retinopathy, medicine.diagnostic_test, business.industry, Retinal Vessels, Retinal, Diabetic retinopathy, medicine.disease, Fluorescein angiography, 3. Good health, Surgery, Arterioles, Diabetes Mellitus, Type 1, Diabetic Retinopathy - Epidemiology - Physiopathology, Blood pressure, chemistry, Diabetes Mellitus, Type 1 - Complications, 030221 ophthalmology & optometry, Female, business, Follow-Up Studies, Retinopathy |
| الوصف: | OBJECTIVE - Alterations in retinal vascular caliber may reflect early subclinical microvascular dysfunction. In this study, we examined the association of retinal vascular caliber to incident retinopathy in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 645 initially retinopathy-free type 1 diabetic patients, aged 12-20 years. Participants had seven-field stereoscopic retinal photographs taken of both eyes at baseline and follow-up. Retinal vascular caliber was measured from baseline photographs using a computer-based program following a standardized protocol. Incident retinopathy was graded according to the modified Airlie House classification from follow-up photographs. RESULTS - Over a median follow-up of 2.5 years, 274 participants developed retinopathy (14.8 per 100 person-years). After adjustments for age, sex, diabetes duration, glycemia, mean arterial blood pressure, BMI, and cholesterol levels, larger retinal arteriolar caliber (fourth versus first quartile) was associated with a more than threefold higher risk of retinopathy (hazard rate ratio 3.44 [95% CI 2.08-5.66]). Each SD increase in retinal arteriolar caliber was associated with a 46% increase in retinopathy risk (1.46 [1.22-1.74]). This association was stronger in female than in male participants. After similar adjustments, retinal venular caliber was not consistently associated with incident retinopathy. CONCLUSIONS - Retinal arteriolar dilatation predicts retinopathy development in young patients with type 1 diabetes. Our data suggest that arteriolar dysfunction may play a critical role in the pathogenesis of early diabetic retinopathy and that computer-based retinal vascular caliber measurements may provide additional prognostic information regarding risk of diabetes micro-vascular complications. © 2008 by the American Diabetes Association. link_to_OA_fulltext |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d604a472c74d90e5a0b08100fda9eaTest https://doi.org/10.2337/dc08-0189Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....35d604a472c74d90e5a0b08100fda9ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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