Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease
| العنوان: | Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease |
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| المؤلفون: | Magdalena Żurawek, Piotr Fichna, Anita Rogowicz-Frontczak, Dorota Zozulińska-Ziółkiewicz, Marek Ruchała, Maria Gryczyńska, Marta Fichna |
| المصدر: | Endocrine |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Adolescent, Genotype, endocrine system diseases, Addison’s disease, Endocrinology, Diabetes and Metabolism, Autoimmunity, 030209 endocrinology & metabolism, Zinc Transporter 8, medicine.disease_cause, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Endocrinology, Addison Disease, Antigen, Risk Factors, Diabetes mellitus, medicine, Humans, ZnT8 autoantibody, Cation Transport Proteins, Aged, Autoantibodies, Aged, 80 and over, Type 1 diabetes, SLC30A8, biology, business.industry, Diabetes, Autoantibody, Middle Aged, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030104 developmental biology, Addison's disease, Immunology, biology.protein, Original Article, Female, Antibody, business |
| الوصف: | Autoimmune Addison’s disease (AAD) associates with exceptional susceptibility to develop other autoimmune conditions, including type 1 diabetes (T1D), marked by positive serum autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and insulinoma-associated protein 2 (IA-2A). Zinc transporter 8 (ZnT8) is a new T1D autoantigen, encoded by the SLC30A8 gene. Its polymorphic variant rs13266634C/T seems associated with the occurrence of serum ZnT8 antibodies (ZnT8A). This study was designed to determine the prevalence of serum ZnT8A and their clinical implication in 140 AAD patients. Other beta cell and thyroid-specific autoantibodies were also investigated, and ZnT8A results were confronted with the rs13266634 genotype. ZnT8A were detectable in 8.5 %, GADA in 20.7 %, IA-2A in 5.7 %, IAA in 1.6 % and various anti-thyroid antibodies in 7.1–67.8 % individuals. Type 1 diabetes was found in 10 % AAD patients. ZnT8A were positive in 57.1 % of T1D patients and 3.4 % non-diabetic AAD. Analysis of ZnT8A enabled to identify autoimmunity in two (14.3 %) T1D individuals previously classified as autoantibody-negative. ZnT8A-positive patients revealed significantly higher number of autoimmune conditions (p |
| تدمد: | 1559-0100 1355-008X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356fb07216cc2ea5dfc56cec3e03a939Test https://doi.org/10.1007/s12020-016-0916-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....356fb07216cc2ea5dfc56cec3e03a939 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590100 1355008X |
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