Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma
| العنوان: | Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma |
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| المؤلفون: | Shoko Yamashita, Yuji Morine, Yusuke Arakawa, Yuma Wada, Shogo Ohta, Satoru Imura, Yoshimi Bando, Tetsuya Ikemoto, Shinichiro Yamada, Yu Saito, Shuichi Iwahashi, Mitsuo Shimada |
| المصدر: | Anticancer Research. 39:6025-6033 |
| بيانات النشر: | Anticancer Research USA Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Multivariate analysis, CA-19-9 Antigen, endocrine system diseases, medicine.medical_treatment, Histone Deacetylase 1, Gastroenterology, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Humans, Intrahepatic Cholangiocarcinoma, Aged, business.industry, Liver Neoplasms, General Medicine, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, digestive system diseases, HDAC1, Gene Expression Regulation, Neoplastic, Survival Rate, Bile Duct Neoplasms, Oncology, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, CA19-9, Neoplasm Recurrence, Local, Hepatectomy, medicine.symptom, business, Carbohydrate antigen, Follow-Up Studies |
| الوصف: | Background/aim Carbohydrate antigen 19-9 (CA19-9) is a poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1α in IHCC. Here, we evaluated the expression and correlation of CA19-9 with HIF-1 and HDAC in IHCC. Patients and methods This study included 62 patients with IHCC who underwent primary hepatectomy at our department. Clinicopathological characteristics were examined. Immunohistochemical expression of HIF-1 and HDAC1 in specimens was quantitatively evaluated. Results Patients with high preoperative serum CA19-9 levels showed clinicopathological characteristics associated with tumour progression. High CA19-9 levels were associated with worse overall and recurrence-free survival. Univariate and multivariate analysis detected high CA19-9 levels as an independent poor prognostic factor for IHCC. Serum CA19-9 was significantly correlated with both HIF-1α and HDAC1 expression. Conclusion High serum CA19-9 level is a poor prognostic factor for overall survival in IHCC and correlates with HIF-1α and HDAC1 expression. |
| تدمد: | 1791-7530 0250-7005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f73c36144da872fa08914d76f7743bTest https://doi.org/10.21873/anticanres.13808Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34f73c36144da872fa08914d76f7743b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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