Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients
| العنوان: | Plasma ratio of clozapine to N-desmethylclozapine can predict cognitive performance in treatment-resistant psychotic patients |
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| المؤلفون: | Maria J. Portella, Cristina Carmona, Marina Piñeiro, C. Molins, Enric Álvarez, Estrella Martínez, Mar Carceller-Sindreu, Helena Navarro |
| المصدر: | PSYCHIATRY RESEARCH r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Serotonin, medicine.medical_specialty, Psychosis, Treatment-resistant psychosis, Dopamine, Treatment-resistant schizophrenia, Schizoaffective disorder, Choline, 03 medical and health sciences, Cognition, 0302 clinical medicine, Internal medicine, medicine, Humans, Effects of sleep deprivation on cognitive performance, Clozapine, Neurocognition, Biological Psychiatry, Aged, Norclozapine, Middle Aged, Prognosis, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Cross-Sectional Studies, Psychotic Disorders, Schizophrenia, Female, Schizophrenic Psychology, Executive functioning, Psychology, Neurocognitive, 030217 neurology & neurosurgery, Antipsychotic Agents, Blood sampling, Clinical psychology, medicine.drug |
| الوصف: | Cognitive symptoms play a central role in schizophrenia and are strongly associated with social functioning. Treatment with clozapine presents controversial results regarding its effects on cognition. The opposite effects of clozapine and n-desmethylclozapine (NDMC) on cholinergic system have been suggested to underlie these inconclusive findings. The aim of this study is to determine whether clozapine/NDMC ratio can predict cognitive performance in patients with treatment-resistant psychosis. Nineteen clinically stable patients with schizophrenia or schizoaffective disorder treated with clozapine monotherapy completed demographic and clinical interviews. For the purpose of the study, patients were assessed with a neuropsychological battery and on the same day a blood sampling was obtained from each patient to measure plasma levels of clozapine and NDMC. Our results showed that clozapine/NDMC ratio, but not clozapine or NDMC plasma levels separately, was a predictive factor of cognitive performance, specifically of executive functioning. Our results showed that lower clozapine/NDMC ratios are associated with better executive functioning in clinically stable patients. These findings could be interpreted by the different pharmacodynamic properties on cholinergic, dopaminergic and serotonergic systems of NDMC compared to clozapine. |
| تدمد: | 0165-1781 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d95dc99beb39558de9c94bb4c6348dTest https://doi.org/10.1016/j.psychres.2017.10.010Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34d95dc99beb39558de9c94bb4c6348d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01651781 |
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