Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: Negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1)
| العنوان: | Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: Negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1) |
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| المؤلفون: | Nemanja Stojanovic, Harpal S. Randeva, Gordana M. Prelevic, Małgorzata Bieńkiewicz, Susan M. Tuck, Paul O'Hare, Bee K. Tan, Krzysztof C. Lewandowski, Martin Press |
| المصدر: | Gynecological Endocrinology. 24:300-305 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Blood Glucose, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Vascular Cell Adhesion Molecule-1, Type 2 diabetes, Statistics, Nonparametric, Endocrinology, Insulin resistance, Pregnancy, Internal medicine, medicine, Humans, Insulin, Retinol binding protein 4, biology, business.industry, nutritional and metabolic diseases, Obstetrics and Gynecology, Glucose Tolerance Test, Intercellular Adhesion Molecule-1, medicine.disease, Obesity, Gestational diabetes, Diabetes, Gestational, biology.protein, Gestation, Female, Insulin Resistance, business, Retinol-Binding Proteins, Plasma, Body mass index, Soluble Vascular Cell Adhesion Molecule 1 |
| الوصف: | Retinol-binding protein-4 (RBP-4) may increase insulin resistance (IR) in animals, with elevated levels reported in humans with obesity and type 2 diabetes. There are, however, few data on concentrations of RBP-4 in gestational diabetes mellitus (GDM).We measured fasting serum levels of RBP-4, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in 50 women at 28 weeks of gestation, divided according to the results of a 50 g glucose challenge test (GCT) and a 75 g oral glucose tolerance test (OGTT): (1) controls (n = 20), normal responses to both GCT and OGTT; (2) intermediate group (IG) (n = 15): false positive GCT, but normal OGTT; and (3) GDM group (n = 15), both GCT and OGTT abnormal. IR was assessed by homeostasis model assessment (HOMA-IR) and by insulin resistance index (IRI) based on glycemia and insulinemia during OGTT.All groups were matched for age and body mass index (BMI). RBP-4 levels (microg/ml, mean+/-standard deviation) were higher in women with GDM vs. controls (53.9 +/- 17.9 vs. 29.7 +/- 13.9, por = 0.001), with a trend towards higher RBP-4 in GDM compared with IG (38.0 +/- 19.3, p = 0.07). There was no significant correlation between RBP-4 and age, BMI, insulin, IRI or HOMA-IR, but there was a moderate, significant negative correlation between RBP-4 and sVCAM-1 (r(2) = 0.20, p = 0.001).RBP-4 levels are elevated in women with GDM, but do not correlate with IR indices and correlate negatively with sVCAM-1. The physiological significance of RBP-4 rise in women with GDM remains to be elucidated. |
| تدمد: | 1473-0766 0951-3590 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3476f3c95fd5f61b9de7d25867aa0959Test https://doi.org/10.1080/09513590802141052Test |
| رقم الانضمام: | edsair.doi.dedup.....3476f3c95fd5f61b9de7d25867aa0959 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730766 09513590 |
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