Epidemiology and clinical characteristics of Klebsiella spp. meningitis in France
| العنوان: | Epidemiology and clinical characteristics of Klebsiella spp. meningitis in France |
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| المؤلفون: | A. Le Monnier, Anaïs Potron, V. Fihman, Eric Farfour, A-G Ranc, Nicolas Degand, J-R Zahar, Olivier Barraud, Emmanuelle Bille, Benoit Pilmis, Laurent Dortet, G Héry-Arnaud, Philippe Morand, G. Pean de Ponfilly, L. Ruffier d’Epenoux, F Laurent, C. Le Brun, C. Piau, Thomas Guillard, Assaf Mizrahi |
| المساهمون: | Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Infectious Diseases Now Infectious Diseases Now, Elsevier, 2021, ⟨10.1016/j.idnow.2021.05.006⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cirrhosis, CSF glucose, Klebsiella pneumoniae, medicine.drug_class, [SDV]Life Sciences [q-bio], Cephalosporin, Neurological disorder, Meningitis, Bacterial, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Klebsiella, Epidemiology, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, 0303 health sciences, biology, 030306 microbiology, business.industry, Mortality rate, biology.organism_classification, medicine.disease, 3. Good health, Klebsiella Infections, Infectious Diseases, France, business, Meningitis |
| الوصف: | Objectives. To describe the epidemiology of Klebsiella spp. meningitis in France with respect to clinical and bacteriological data. Methods. We performed a four-year multicenter, retrospective, observational study. The primary objective was to provide a clinical description of patients with Klebsiella spp. meningitis. Secondary objectives were to compare community-acquired meningitis and healthcare-associated meningitis and to analyze factors associated with mortality. Results. We enrolled 131 patients with Klebsiella spp. meningitis. Eighty-two (62.6%) infections were reported following neurosurgery. Twenty-eight strains (21.4%) were resistant to third-generation cephalosporins (3GC). The median [IQR] cellularity was 980/mm3 [116-5,550], the median protein level was 5.67 [1.62-9] g/L and the median CSF glucose level was 2.5 [0-3.4] mmol/L. The in-hospital mortality rate was 23.6%. Community-acquired meningitis isolates were more frequently susceptible to 3GC than isolates from healthcare-associated meningitis (89.2% versus 72%; p=0.04). Comorbidities reported for patients with community-acquired meningitis were mainly diabetes mellitus and liver cirrhosis. In multivariate analysis, focal neurological disorder at the time of diagnosis was the only factor associated with in-hospital mortality (p=0.01). Conclusions. Purulent meningitis caused by Klebsiella spp. needs to be considered in patients with community-acquired meningitis and pre-existing conditions, as well as in case of meningitis following neurosurgical procedures. |
| تدمد: | 2666-9919 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3471d39c09c43fc92ffbfeeae475cc1bTest https://pubmed.ncbi.nlm.nih.gov/35914712Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3471d39c09c43fc92ffbfeeae475cc1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26669919 |
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