Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes

التفاصيل البيبلوغرافية
العنوان: Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes
المؤلفون: Sanna Tiainen, Antti M. Kiviniemi, Mikko P. Tulppo, Tommi Vasankari, Heikki V. Huikuri, Kari Tokola, Arto J. Hautala, Olavi Ukkola
المصدر: Antioxidants, Vol 7, Iss 10, p 144 (2018)
Antioxidants
Volume 7
Issue 10
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
مصطلحات موضوعية: medicine.medical_specialty, Physiology, Clinical Biochemistry, Blood lipids, Type 2 diabetes, 030204 cardiovascular system & hematology, Biochemistry, Article, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, medicine, 030212 general & internal medicine, oxidized HDL lipids, Molecular Biology, exercise, business.industry, lcsh:RM1-950, Decreased Concentration, Cell Biology, ta3121, medicine.disease, serum lipids, lcsh:Therapeutics. Pharmacology, Cardiology, lipids (amino acids, peptides, and proteins), Training program, business, oxidized LDL lipids, Oxidized ldl, Lipoprotein
الوصف: We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on the determination of baseline conjugated dienes in lipoprotein lipids. In order to study the effect of an exercise load on ox-LDL and ox-HDL lipids patients in both CAD and CAD + T2D intervention, groups were divided in three based on exercise load (high, medium, and low). During the two-year home-based exercise training program, the study showed that only higher training volume resulted in a decreased concentration of ox-LDL, while the two groups with lower training volumes showed no change. This result indicates that the training load needs to be sufficiently high in order to decrease the concentration of atherogenic ox-LDL lipids in patients with CAD and CAD + T2D. Interestingly, the concentration of ox-HDL did not change in any of the subgroups. This could indicate that the lipid peroxide-transporting capacity of HDL, suggested by results from exercise training studies in healthy adults, may not function similarly in CAD patients with or without T2D. Moreover, the lipid-lowering medication used may have had an influence on these results.
وصف الملف: application/pdf
اللغة: English
تدمد: 2076-3921
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34348ad78e3078dc13654168481e8151Test
http://www.mdpi.com/2076-3921/7/10/144Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....34348ad78e3078dc13654168481e8151
قاعدة البيانات: OpenAIRE