Comparative effectiveness of cladribine tablets versus other oral disease-modifying treatments for multiple sclerosis: Results from MSBase registry
| العنوان: | Comparative effectiveness of cladribine tablets versus other oral disease-modifying treatments for multiple sclerosis: Results from MSBase registry |
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| المؤلفون: | Tim Spelman, Serkan Ozakbas, Raed Alroughani, Murat Terzi, Suzanne Hodgkinson, Guy Laureys, Tomas Kalincik, Anneke Van Der Walt, Bassem Yamout, Jeannette Lechner-Scott, Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Yolanda Blanco Morgado, Daniele LA Spitaleri, Vincent van Pesch, Dana Horakova, Radek Ampapa, Francesco Patti, Richard Macdonell, Abdullah Al-Asmi, Oliver Gerlach, Jiwon Oh, Ayse Altintas, Namita Tundia, Schiffon L Wong, Helmut Butzkueven |
| المساهمون: | UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Spelman, T., Ozakbas, S., Alroughani, R., Terzi, M., Hodgkinson, S., Laureys, G., Kalincik, T., Van Der Walt, A., Yamout, B., Lechner-Scott, J., Soysal, A., Kuhle, J., Sanchez-Menoyo, J.L., Blanco Morgado, Y., Spitaleri, D., van Pesch, V., Horakova, D., Ampapa, R., Patti, F., Macdonell, R., Al-Asmi, A., Gerlach, O., Oh, J., Tundia, N., Wong, S.L., Butzkueven, H., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine |
| المصدر: | Multiple Sclerosis, Vol. 29, no.2, p. 221-235 (2023) Multiple Sclerosis Journal MULTIPLE SCLEROSIS JOURNAL |
| بيانات النشر: | Demos Medical Publishing, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | relapse, Multiple Sclerosis, real-world data, Fingolimod Hydrochloride, switching, Dimethyl Fumarate, Neurosciences and neurology, MS, registry, Multiple Sclerosis, Relapsing-Remitting, Disability, Discontinuation, Real-world data, Registry, Relapse, Switching, Neurology, disability, Recurrence, Medicine and Health Sciences, Humans, Cladribine, Neurology (clinical), Registries, Immunosuppressive Agents, Retrospective Studies, Tablets, discontinuation |
| الوصف: | Background: effectiveness of cladribine tablets, an oral disease-modifying treatment (DMT) for multiple sclerosis (MS), was established in clinical trials and confirmed with real-world experience. Objectives: use real-world data to compare treatment patterns and clinical outcomes in people with MS (pwMS) treated with cladribine tablets versus other oral DMTs. Methods: retrospective treatment comparisons were based on data from the international MSBase registry. Eligible pwMS started treatment with cladribine, fingolimod, dimethyl fumarate, or teriflunomide tablets from 2018 to mid-2021 and were censored at treatment discontinuation/switch, death, loss to follow-up, pregnancy, or study period end. Treatment persistence was evaluated as time to discontinuation/switch; relapse outcomes included time to first relapse and annualized relapse rate (ARR). Results: cohorts included 633 pwMS receiving cladribine tablets, 1195 receiving fingolimod, 912 receiving dimethyl fumarate, and 735 receiving teriflunomide. Individuals treated with fingolimod, dimethyl fumarate, or teriflunomide switched treatment significantly more quickly than matched cladribine tablet cohorts (adjusted hazard ratio (95% confidence interval): 4.00 (2.54-6.32), 7.04 (4.16-11.93), and 6.52 (3.79-11.22), respectively). Cladribine tablet cohorts had significantly longer time-to-treatment discontinuation, time to first relapse, and lower ARR, compared with other oral DMT cohorts. Conclusion: cladribine tablets were associated with a significantly greater real-world treatment persistence and more favorable relapse outcomes than all oral DMT comparators. Financial support for this study was provided entirely by a contract with EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA (CrossRef Funder ID: 10.13039/100004755). The funding agreement ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. The following authors are employed by the sponsor: NT and SLW. |
| وصف الملف: | pdf; application/pdf |
| اللغة: | English |
| تدمد: | 1352-4585 1477-0970 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ee715dacc56947073a0f738d2a8ef5Test https://hdl.handle.net/2078.1/276372Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....33ee715dacc56947073a0f738d2a8ef5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13524585 14770970 |
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