Central Hypothyroidism Related to Pituitary Adenomas: Low Incidence of Central Hypothyroidism in Patients With Acromegaly
| العنوان: | Central Hypothyroidism Related to Pituitary Adenomas: Low Incidence of Central Hypothyroidism in Patients With Acromegaly |
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| المؤلفون: | Satoshi Yoshino, Takashi Okamura, Tetsuya Takamizawa, Shozo Yamada, Tsugumichi Saitoh, Masanobu Yamada, Kazuhiko Horiguchi, Eijiro Yamada, Masahiko Tosaka, Emi Ishida, Atsushi Ozawa, Yasuyo Nakajima, Shunichi Matsumoto |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 104:4879-4888 |
| بيانات النشر: | The Endocrine Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Thyroid Function Tests, Biochemistry, Thyroid function tests, Endocrinology, Hypothyroidism, Pituitary adenoma, Internal medicine, Acromegaly, medicine, Central hypothyroidism, Humans, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Incidence, Incidence (epidemiology), Biochemistry (medical), Thyroid, Middle Aged, medicine.disease, Cross-Sectional Studies, medicine.anatomical_structure, Female, Growth Hormone-Secreting Pituitary Adenoma, Thyroid function, business |
| الوصف: | ContextThe most frequent cause of central hypothyroidism (CeH) is pituitary adenomas, but the mechanisms remain unclear.ObjectiveWe investigated serum thyroid levels and GH/IGF-1 in central hypothyroidism in untreated patients with pituitary nonfunctioning and GH-secreting adenomas.DesignThis was a retrospective cross-sectional study of cases collected from Gunma University and Toranomon Hospitals between 2007 and 2016.PatientsOne-hundred thirty-nine cases of nonfunctioning pituitary adenoma (NFPA) and 150 cases of GH-secreting pituitary adenoma (GHPA) were analyzed.Main Outcome MeasuresThe correlations between thyroid levels, several clinicopathological parameters, and GH/IGF-1 were examined.ResultsTwenty-four percent of NFPA patients had CeH. The severity did not correlate with tumor size, age, or sex, and all cases had normal TSH levels. In contrast, only 8.7% of GHPA patients had CeH; approximately half had normal TSH levels and approximately half had low TSH levels. Serum TSH levels in GHPA patients were significantly lower and free T4 (FT4) and free T3 levels were higher than those in patients with NFPA. Furthermore, approximately one-fourth of GHPA patients had normal FT4 and low TSH levels. In addition, serum FT4 levels and serum TSH levels were positively and negatively correlated, respectively, with serum IGF-1 levels. Furthermore, IGF-1 levels in patients with GHPA decreased with age.Conclusions(i) NFPA patients with CeH had TSH levels within a normal range. (ii) GHPA patients had a low incidence of CeH, which may be a result of stimulated thyroid function by GH/IGF-1. (iii) We found an age-dependent decrease in serum IGF-1 levels in patients with GHPA. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3350da4655a85300a3cc6eae0b846ab7Test https://doi.org/10.1210/jc.2019-00466Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3350da4655a85300a3cc6eae0b846ab7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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