Different Subsets of Circulating Angiogenic Cells Do not Predict Bronchopulmonary Dysplasia or other Diseases of Prematurity in Preterm Infants
| العنوان: | Different Subsets of Circulating Angiogenic Cells Do not Predict Bronchopulmonary Dysplasia or other Diseases of Prematurity in Preterm Infants |
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| المؤلفون: | A. W D Gavilanes, Lina Bollani, Diego Gazzolo, Vittorio Rosti, Chryssoula Tzialla, Mauro Stronati, Paolo Manzoni, Rita Campanelli, Stefania Longo, M. Massa, Iolanda Mazzucchelli, R. Cabano, Alessandro Borghesi, Francesca Garofoli, Arsenio Spinillo |
| المصدر: | Scopus-Elsevier ResearcherID |
| بيانات النشر: | SAGE Publications, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neonatal intensive care unit, medicine.medical_treatment, Birth weight, Immunology, CD34, Antigens, CD34, Gestational Age, Gastroenterology, Tertiary Care Centers, Leukocyte Count, Antigens, CD, Predictive Value of Tests, Risk Factors, Internal medicine, mental disorders, medicine, Humans, Infant, Very Low Birth Weight, Immunology and Allergy, AC133 Antigen, Bronchopulmonary Dysplasia, Glycoproteins, Retrospective Studies, Pharmacology, Mechanical ventilation, Lung, Neovascularization, Pathologic, business.industry, Gestational age, Retrospective cohort study, Flow Cytometry, Hematopoietic Stem Cells, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, Phenotype, medicine.anatomical_structure, Bronchopulmonary dysplasia, Leukocyte Common Antigens, Peptides, business, Biomarkers, Infant, Premature |
| الوصف: | Bronchopulmonary dysplasia (BPD) is a chronic lung disease occurring in very and extremely preterm infants undergoing mechanical ventilation. Given the altered lung vascular growth characterizing BPD, circulating angiogenic cells could be useful biomarkers to predict the risk. The objective of the study was to determine whether the percentages of circulating angiogenic cells (CD34+VEGFR-2+, CD34+CD133+VEGFR-2+, and CD45-CD34+CD133+VEGFR-2+ cells), assessed in the peripheral blood at birth by flow cytometry, could be used as markers for the risk of BPD. In one-hundred and forty-two preterm neonates (gestational age < 32 weeks and/or birth weight < 1500 g) admitted to our tertiary care Neonatal Intensive Care Unit between 2006 and 2009, we evaluated the percentages of circulating angiogenic cells at birth, at 7 days, and, in a subset of infants (n=40), at 28 days of life. The main outcome was the correlation between cell counts at birth and the subsequent risk of developing BPD. In our study, all the three cell populations failed to predict the development of BPD or other diseases of prematurity. We suggest that these cells cannot be used as biomarkers in preterm infants, and that research is needed to find other early predictors of BPD. |
| تدمد: | 2058-7384 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3337a1a6768d759a3590adc7358ac943Test https://doi.org/10.1177/039463201302600330Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3337a1a6768d759a3590adc7358ac943 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20587384 |
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