European Federation of Neurological Societies cutoff values significantly reduce creatine kinase sensitivity for diagnosing neuromuscular disorders
| العنوان: | European Federation of Neurological Societies cutoff values significantly reduce creatine kinase sensitivity for diagnosing neuromuscular disorders |
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| المؤلفون: | Vera Bril, Hans D. Katzberg, Leif E. Lovblom, Alon Abraham |
| المصدر: | Muscle & Nerve. 60:748-752 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Neuromuscular disease, Demographics, Physiology, Test sensitivity, 030105 genetics & heredity, Gastroenterology, Polyneuropathies, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Muscular Diseases, Reference Values, Physiology (medical), Internal medicine, medicine, Humans, Cutoff, Motor Neuron Disease, Myopathy, Creatine Kinase, Societies, Medical, Aged, biology, business.industry, Neuromuscular Diseases, Middle Aged, medicine.disease, Europe, Neurology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Area Under Curve, biology.protein, Female, Creatine kinase, Neurology (clinical), Electronic database, medicine.symptom, business, Polyneuropathy, 030217 neurology & neurosurgery |
| الوصف: | INTRODUCTION Elevated creatine kinase (CK) level was redefined by the European Federation of Neurological Societies)EFNS(as 1.5 times the upper limit of normal. In the current study we sought to determine the sensitivity and specificity of CK testing for the diagnosis of neuromuscular disorders. METHODS Demographics and CK levels were retrospectively extracted from an electronic database for 234 patients with neuromuscular disorders. Sensitivity, specificity, and likelihood ratios and the area under curve were determined for each diagnosis and different cutoff CK values. RESULTS Using the EFNS cutoff values significantly reduced CK test sensitivity. Creatine kinase values >1000 IU/L showed a high likelihood (11.04) for myopathies and a low likelihood for polyneuropathies (0). DISCUSSION European Federation of Neurological Societies cutoff values significantly reduce CK sensitivity for diagnosing neuromuscular disorders. While low CK values cannot exclude a neuromuscular disease, values >1000 IU/L are associated with a high likelihood of myopathy. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e816dd1c956e20aec284c659b929e6Test https://doi.org/10.1002/mus.26701Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....32e816dd1c956e20aec284c659b929e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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