Paranasal sinusitis at the initiation of chemotherapy is a risk factor for invasive fungal disease in children and adolescents with cancer
| العنوان: | Paranasal sinusitis at the initiation of chemotherapy is a risk factor for invasive fungal disease in children and adolescents with cancer |
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| المؤلفون: | Kenji Kishimoto, Masato Yanagi, Kunihiko Kobayashi, Daisuke Suzuki, Satoru Matsushima, Ryoji Kobayashi, Hirozumi Sano, Daiki Hori |
| المصدر: | Supportive Care in Cancer. 29:5847-5852 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Antifungal Agents, Adolescent, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Cumulative incidence, 030212 general & internal medicine, Sinusitis, Risk factor, Child, Retrospective Studies, Chemotherapy, business.industry, Septic shock, Incidence (epidemiology), Cancer, Retrospective cohort study, medicine.disease, Leukemia, Myeloid, Acute, Oncology, 030220 oncology & carcinogenesis, Bacteremia, business, Invasive Fungal Infections |
| الوصف: | The impact of paranasal sinusitis on the clinical outcome of patients with cancer remains unknown. The aim of this study was to determine whether paranasal sinusitis at the initiation of chemotherapy (SAI) affects the development of infectious complications in children and adolescents with cancer. A retrospective cohort analysis of patients aged 0-20 years with cancer who received chemotherapy was performed. SAI was defined as the presence of a fluid level or mucosal swelling or total opacity on sinus computed tomography examination before the initiation of chemotherapy. The primary outcome measures were the incidence of bacteremia, septic shock, and invasive fungal disease (IFD, including proven, probable, and possible cases). SAI was observed in 57 (44%) of 130 enrolled patients. There were no significant differences in age, sex, and disease distribution between the patients with SAI (SAI group) and those without (non-SAI group). There was no significant difference in the 1-year cumulative incidence of bacteremia or septic shock after treatment initiation between the two groups (bacteremia, SAI group 33% vs. non-SAI group 35%, P = 0.53; septic shock, SAI group 4% vs. non-SAI group 4%, P = 0.87). The 1-year cumulative incidence of IFD was higher in the SAI group than in the non-SAI group (22% vs. 6%, P = 0.012). Cumulative incidence analysis after inverse probability of treatment weighting adjustment showed that the SAI group was more likely to develop IFD (HR: 3.5, 95% CI: 1.1-11.2, P = 0.033). Our findings suggest that patients with SAI may be at higher risk for IFD during chemotherapy. |
| تدمد: | 1433-7339 0941-4355 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329aecb917e511cd7797fc20decc0882Test https://doi.org/10.1007/s00520-021-06143-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....329aecb917e511cd7797fc20decc0882 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14337339 09414355 |
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