A polymer physics view on universal and sequence-specific aspects of chromosome folding
| العنوان: | A polymer physics view on universal and sequence-specific aspects of chromosome folding |
|---|---|
| المؤلفون: | Ralf Everaers, Daniel Jost, Cédric Vaillant, Angelo Rosa |
| المساهمون: | Biologie Computationnelle et Mathématique (TIMC-IMAG-BCM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Jost, Daniel, École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon |
| المصدر: | Nuclear Architecture and Dynamics Nuclear Architecture and Dynamics, Elsevier, pp.149-169, 2018 HAL |
| بيانات النشر: | Academic Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Physics, Nuclear gene, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Chromosome, Sequence (biology), Computational biology, Chromatin, Settore FIS/03 - Fisica della Materia, Folding (chemistry), 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Polymer physics, Statistical physics, 030217 neurology & neurosurgery, Topology (chemistry), ComputingMilieux_MISCELLANEOUS, Chromatin Fiber |
| الوصف: | Recent advances in genome-wide mapping and imaging techniques have strikingly improved the resolution at which nuclear genome folding can be analyzed and revealed numerous conserved features organizing the one-dimensional chromatin fiber into tridimensional nuclear domains. Understanding the underlying mechanisms and the link to gene regulation requires a crossdisciplinary approach that combines the new high-resolution techniques with computational modeling of chromatin and chromosomes. The present chapter discusses our current understanding of generic aspects of chromosome behavior during interphase. In particular, we present explanations from polymer physics for the emergence of the universal “territorial” folding of chromosomes above the Mbp scale and the sequence-dependent formation of topologically associating domains below the Mbp scale. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32242808361d04c0e0df650c3e341e0bTest http://hdl.handle.net/20.500.11767/63919Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32242808361d04c0e0df650c3e341e0b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |