Bacterial mandelic acid degradation pathway and its application in biotechnology
| العنوان: | Bacterial mandelic acid degradation pathway and its application in biotechnology |
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| المؤلفون: | Qingzhuo Wang, Shanshan Geng, Lingru Wang, Zhiqiang Wen, Xiaoman Sun, He Huang |
| المصدر: | Journal of Applied Microbiology. 133:273-286 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Kinetics, Pseudomonas putida, Mandelic Acids, General Medicine, Oxidoreductases, Applied Microbiology and Biotechnology, Biotechnology |
| الوصف: | Mandelic acid and its derivatives are an important class of chemical synthetic blocks, which is widely used in drug synthesis and stereochemistry research. In nature, mandelic acid degradation pathway has been widely identified and analysed as a representative pathway of aromatic compounds degradation. The most studied mandelic acid degradation pathway from Pseudomonas putida consists of mandelate racemase, S-mandelate dehydrogenase, benzoylformate decarboxylase, benzaldehyde dehydrogenase and downstream benzoic acid degradation pathways. Because of the ability to catalyse various reactions of aromatic substrates, pathway enzymes have been widely used in biocatalysis, kinetic resolution, chiral compounds synthesis or construction of new metabolic pathways. In this paper, the physiological significance and the existing range of the mandelic acid degradation pathway were introduced first. Then each of the enzymes in the pathway is reviewed one by one, including the researches on enzymatic properties and the applications in biotechnology as well as efforts that have been made to modify the substrate specificity or improving catalytic activity by enzyme engineering to adapt different applications. The composition of the important metabolic pathway of bacterial mandelic acid degradation pathway as well as the researches and applications of pathway enzymes is summarized in this review for the first time. |
| تدمد: | 1365-2672 1364-5072 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313110c2dd610b449813955b8c3feebfTest https://doi.org/10.1111/jam.15529Test |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....313110c2dd610b449813955b8c3feebf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652672 13645072 |
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