Theobromine does not affect postprandial lipid metabolism and duodenal gene expression, but has unfavorable effects on postprandial glucose and insulin responses in humans
| العنوان: | Theobromine does not affect postprandial lipid metabolism and duodenal gene expression, but has unfavorable effects on postprandial glucose and insulin responses in humans |
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| المؤلفون: | Ronald P. Mensink, Rogier de Ridder, Jogchum Plat, Lotte Smolders, Mark V. Boekschoten |
| المساهمون: | RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Promovendi NTM, Humane Biologie, Nutrition and Movement Sciences, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9) |
| المصدر: | Clinical Nutrition 37 (2018) 2 Clinical Nutrition, 37(2), 719-727. Churchill Livingstone Clinical Nutrition, 37(2), 719-727 |
| بيانات النشر: | Churchill Livingstone, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Blood Glucose, Male, 0301 basic medicine, COCOA, medicine.medical_treatment, Gene Expression, Blood lipids, BLOOD-PRESSURE, Microarray, Critical Care and Intensive Care Medicine, Voeding, Metabolisme en Genomica, chemistry.chemical_compound, 0302 clinical medicine, Blood serum, HDL-CHOLESTEROL, Reference Values, Insulin, Glucose metabolism, Cross-Over Studies, Nutrition and Dietetics, Postprandial, Middle Aged, RANDOMIZED CONTROLLED-TRIAL, Postprandial Period, Metabolism and Genomics, C-REACTIVE PROTEIN, Metabolisme en Genomica, Theobromine, Female, Nutrition, Metabolism and Genomics, lipids (amino acids, peptides, and proteins), medicine.drug, medicine.medical_specialty, Duodenum, 030209 endocrinology & metabolism, DARK CHOCOLATE, Carbohydrate metabolism, 03 medical and health sciences, TYPE-2, Double-Blind Method, Voeding, Internal medicine, medicine, Humans, METAANALYSIS, VLAG, Nutrition, Cholesterol, business.industry, Lipid metabolism, CONSUMPTION, Microarray Analysis, 030104 developmental biology, Endocrinology, chemistry, FAT, business |
| الوصف: | Background & aims: Chocolate consumption is associated with a decreased risk for CVD. Theobromine, a compound in cocoa, may explain these effects as it favorably affected fasting serum lipids. However, long-term effects of theobromine on postprandial metabolism as well as underlying mechanisms have never been studied. The objective was to evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial lipid, lipoprotein and glucose metabolism, and duodenal gene expression.Methods: In a randomized, double-blind crossover study, 44 healthy men and women, with low baseline HDL-C concentrations consumed 500 mg theobromine or placebo daily. After 4-weeks, fasting blood was sampled and subjects participated in a 4-h postprandial test. Blood was sampled frequently for analysis of lipid and glucose metabolism. In a subgroup of 10 men, 5 h after meal consumption duodenal biopsies were taken for microarray analysis.Results: 4-weeks theobromine consumption lowered fasting LDL-C (-0.21 mmol/L; P = 0.006), and apoB100 (-0.04 g/L; P = 0.022), tended to increase HDL-C (0.03 mmol/L; P = 0.088) and increased hsCRP (1.2 mg/L; P = 0.017) concentrations. Fasting apoA-I, TAG, FFA, glucose and insulin concentrations were unchanged. In the postprandial phase, theobromine consumption increased glucose (P = 0.026), insulin (P = 0,011) and FFA (P = 0.003) concentrations, while lipids and (apo)lipoproteins were unchanged. In duodenal biopsies, microarray analysis showed no consistent changes in expression of genes, pathways or gene sets related to lipid, cholesterol or glucose metabolism.Conclusions: It is not likely that the potential beneficial effects of cocoa on CVD can be ascribed to theobromine. Although theobromine lowers serum LDL-C concentrations, it did not change fasting HDL-C, apoA-I, or postprandial lipid concentrations and duodenal gene expression, and unfavorably affected postprandial glucose and insulin responses. This trial was registered on clinicaltrials.gov under study number NCT02209025. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 1532-1983 0261-5614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30962ae6af2af9f68628b421a9d7dfcdTest https://cris.maastrichtuniversity.nl/en/publications/a2cc8c9b-208b-4837-96a7-390c6447b771Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30962ae6af2af9f68628b421a9d7dfcd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321983 02615614 |
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