Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study
| العنوان: | Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study |
|---|---|
| المؤلفون: | Yasser Nassar, Sherif Mokhtar, Mohamed Saeed, Ahmed Mokhtar, Akram Eladawy, Yasser Sakr, Samuel Buschbeck, Amr Elhadidy, Mostafa Elshazly, Farouk Mostafa, Marwa Elsayed, Ashraf Rady |
| المصدر: | Journal of Infection and Public Health, Vol 14, Iss 10, Pp 1381-1388 (2021) Journal of Infection and Public Health |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, HFO, High flow oxygen therapy, 0301 basic medicine, Hospital mortality, ICU, Intensive Care unit, PO2, Partial pressure of oxygen, Disease, Infectious and parasitic diseases, RC109-216, law.invention, Hospitals, University, FiO2, Fraction of inspired oxygen, 0302 clinical medicine, Risk Factors, Interquartile range, law, SD, Standard deviation, 030212 general & internal medicine, General Medicine, Middle Aged, Intensive care unit, Intensive Care Units, IU, International unit, Infectious Diseases, ECMO, Extracorporeal membrane oxygenation, Cohort, CRP, C-reactive protein, Egypt, Female, Public aspects of medicine, RA1-1270, medicine.medical_specialty, Ischemic heart disease, 030106 microbiology, BMI, Body mass index, Lower risk, COVID-19, Coronavirus disease-2019, 03 medical and health sciences, Internal medicine, Intensive care, Pneumonia, Bacterial, APACHE II, Acute Physiology and Chronic Health Evaluation II, medicine, Humans, IQ, Interquartile range, Aged, Retrospective Studies, PCO2, Partial pressure of carbon dioxide, SaO2, Arterial oxygen concentration, LDH, Lactate dehydrogenase, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, business.industry, SARS-CoV-2, ALT, Alanine aminotransferase, Public Health, Environmental and Occupational Health, COVID-19, Retrospective cohort study, Original Articles, medicine.disease, AST, Aspartate transaminase, Pneumonia, business |
| الوصف: | Background The characteristics, outcomes, and risk factors for in-hospital death of critically ill intensive care unit (ICU) patients with coronavirus disease-2019 (COVID-19) have been described in patients from Europe, North America and China, but there are few data from COVID-19 patients in Middle Eastern countries. The aim of this study was to investigate the characteristics, outcomes, and risk factors for in-hospital death of critically ill patients with COVID-19 pneumonia admitted to the ICUs of a University Hospital in Egypt. Methods Retrospective analysis of patients with COVID-19 pneumonia admitted between April 28 and July 29, 2020 to two ICUs dedicated to the isolation and treatment of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in Cairo University Hospitals. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples and radiologic evidence of pneumonia. Results Of the 177 patients admitted to the ICUs during the study period, 160 patients had COVID-19 pneumonia and were included in the analysis (mean age: 60 ± 14 years, 67.5% males); 23% of patients had no known comorbidities. The overall ICU and hospital mortality rates were both 24.4%. The ICU and hospital lengths of stay were 7 (25–75% interquartile range: 4–10) and 10 (25–75% interquartile range: 7–14) days, respectively. In a multivariable analysis with in-hospital death as the dependent variable, ischemic heart disease, history of smoking, and secondary bacterial pneumonia were independently associated with a higher risk of in-hospital death, whereas greater PaO2/FiO2 ratio on admission to the ICU was associated with a lower risk. Conclusion In this cohort of critically ill patients with COVID-19 pneumonia, ischemic heart disease, history of smoking, and secondary bacterial pneumonia were independently associated with a higher risk of in-hospital death. |
| اللغة: | English |
| تدمد: | 1876-0341 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307c5b078c152d50f75c418dc71307cfTest http://www.sciencedirect.com/science/article/pii/S1876034121001787Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....307c5b078c152d50f75c418dc71307cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18760341 |
|---|