Epigenetic reprogramming of immune cells in injury, repair, and resolution
| العنوان: | Epigenetic reprogramming of immune cells in injury, repair, and resolution |
|---|---|
| المؤلفون: | Joachim L. Schultze, Katarzyna Placek, Anna C. Aschenbrenner |
| المصدر: | Journal of Clinical Investigation J Clin Invest The journal of clinical investigation 129(8), 2994-3005 (2019). doi:10.1172/JCI124619 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, immunology [Protein Processing, Post-Translational], Myocardial Infarction, immunology [Cellular Reprogramming], immunology [Histones], Chromatin remodeling, Epigenesis, Genetic, Histones, 03 medical and health sciences, immunology [Myocardial Infarction], 0302 clinical medicine, Immune system, immunology [Epigenesis, Genetic], Animals, Humans, ddc:610, Epigenetics, Epigenesis, biology, Review Series, pathology [Myocardial Infarction], epigenetics, injury, immune system, inflammation, General Medicine, DNA Methylation, Cellular Reprogramming, Cell biology, Stroke, 030104 developmental biology, Histone, 030220 oncology & carcinogenesis, DNA methylation, pathology [Stroke], biology.protein, Stem cell, Protein Processing, Post-Translational, Reprogramming, immunology [Stroke], immunology [DNA Methylation] |
| الوصف: | Immune cells are pivotal in the reaction to injury, whereupon, under ideal conditions, repair and resolution phases restore homeostasis following initial acute inflammation. Immune cell activation and reprogramming require transcriptional changes that can only be initiated if epigenetic alterations occur. Recently, accelerated deciphering of epigenetic mechanisms has extended knowledge of epigenetic regulation, including long-distance chromatin remodeling, DNA methylation, posttranslational histone modifications, and involvement of small and long noncoding RNAs. Epigenetic changes have been linked to aspects of immune cell development, activation, and differentiation. Furthermore, genome-wide epigenetic landscapes have been established for some immune cells, including tissue-resident macrophages, and blood-derived cells including T cells. The epigenetic mechanisms underlying developmental steps from hematopoietic stem cells to fully differentiated immune cells led to development of epigenetic technologies and insights into general rules of epigenetic regulation. Compared with more advanced research areas, epigenetic reprogramming of immune cells in injury remains in its infancy. While the early epigenetic mechanisms supporting activation of the immune response to injury have been studied, less is known about resolution and repair phases and cell type-specific changes. We review prominent recent findings concerning injury-mediated epigenetic reprogramming, particularly in stroke and myocardial infarction. Lastly, we illustrate how single-cell technologies will be crucial to understanding epigenetic reprogramming in the complex sequential processes following injury. |
| تدمد: | 0021-9738 |
| DOI: | 10.1172/jci124619 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3036ba638e8a12b1d3f0f9bfa779f18cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3036ba638e8a12b1d3f0f9bfa779f18c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00219738 |
|---|---|
| DOI: | 10.1172/jci124619 |