Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men
| العنوان: | Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men |
|---|---|
| المؤلفون: | Sørensen, Lars P, Andersen, Iben Rahbek, Larsen, Svend Erik, Søndergaard, Esben, Gormsen, Lars C, Schmitz, Ole, Christiansen, Jens S, Nielsen, Søren |
| المصدر: | Sørensen, L P, Andersen, I R, Larsen, S E, Søndergaard, E, Gormsen, L C, Schmitz, O, Christiansen, J S & Nielsen, S 2011, ' Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men ', Diabetes, vol. 60, no. 1, pp. 88-96 . https://doi.org/10.2337/db10-0564Test Diabetes |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Adipose tissue, Fatty Acids, Nonesterified, Lipoproteins, VLDL, Biology, chemistry.chemical_compound, Basal (phylogenetics), Reference Values, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Hyperinsulinemia, Humans, Insulin, Triglycerides, Aged, Glycated Hemoglobin, Cholesterol, Cholesterol, HDL, Fatty Acids, nutritional and metabolic diseases, Cholesterol, LDL, Middle Aged, medicine.disease, Metabolism, Clamp, Endocrinology, Adipose Tissue, Diabetes Mellitus, Type 2, chemistry, Isotope Labeling, lipids (amino acids, peptides, and proteins), Energy Intake, Lipoprotein |
| الوصف: | OBJECTIVE Increased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia. The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type 2 diabetic and healthy (nondiabetic) men. RESEARCH DESIGN AND METHODS Eleven type 2 diabetic and 11 healthy men, matched for BMI and age, were included. Ex vivo-labeled VLDL-TG tracers, blood and breath samples, fat biopsies, indirect calorimetry, and body composition measures were applied to determine VLDL-TG kinetics, VLDL-TG fatty acids (FA) oxidation, and storage in regional adipose tissue before and during a hyperinsulinemic euglycaemic clamp. RESULTS VLDL-TG secretion was significantly greater in diabetic compared with healthy men (basal: 86.9 [31.0] vs. 61.9 [30.0] μmol/min, P = 0.03; clamp: 60.0 [26.2] vs. 34.2 [17.9] μmol · min−1, P = 0.01). The insulin mediated suppression of VLDL-TG secretion was significant in both groups. VLDL-TG clearance was lower in diabetic men (basal: 84.6 [32.7] vs. 115.4 [44.3] ml · min−1, P = 0.08; clamp: 76.3 [30.6] vs. 119.0 [50.2] ml · min−1, P = 0.03). During hyperinsulinemia fractional VLDL-TG FA oxidation was comparable, but in percentage of energy expenditure (EE), significantly higher in diabetic men. Basal VLDL-TG storage was similar, but significantly greater in abdominal compared with leg fat. CONCLUSIONS Increased VLDL-TG in type 2 diabetic men is caused by greater VLDL-TG secretion and less so by lower VLDL-TG clearance. The ability of hyperinsulinemia to suppress VLDL-TG secretion appears preserved. During hyperinsulinemia VLDL-TG FA oxidation is significantly increased in proportion of EE in type 2 diabetic men. Greater basal abdominal VLDL-TG storage may help explain the accumulation of upper-body fat in insulin-resistant individuals. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb824f7924d41b7df41a12c2409800bTest https://pure.au.dk/portal/da/publications/basal-and-insulin-mediated-vldltriglyceride-kinetics-in-type-2-diabetic-menTest(184bc850-c7b2-11df-8cb9-000ea68e967b).html |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2fb824f7924d41b7df41a12c2409800b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |