APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment
| العنوان: | APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment |
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| المؤلفون: | Marino Zerial, Sandrine Uttenweiler-Joseph, Savvas Christoforidis, Angelika Giner, Marta Miaczynska, Bianca Habermann, Robert G. Parton, Anna Shevchenko, Matthias Wilm |
| المساهمون: | Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Max-Planck-Gesellschaft, European Molecular Biology Laboratory [Heidelberg] (EMBL), Institute for Molecular Bioscience, University of Queensland [Brisbane] |
| المصدر: | Cell Cell, Elsevier, 2004, 116 (3), pp.445-456. ⟨10.1016/s0092-8674(04)00117-5⟩ ResearcherID |
| بيانات النشر: | Elsevier BV, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Plasma protein binding, Binding Sites/genetics, Cell membrane, Transduction (genetics), 0302 clinical medicine, Endocytosis/*physiology, Carrier Proteins/genetics/*metabolism, Histone Deacetylases/genetics, 0303 health sciences, rab5 GTP-Binding Proteins/genetics/*metabolism, Cell Division/genetics, Endocytosis, Cell biology, Protein Transport, Cell Compartmentation/genetics, medicine.anatomical_structure, Guanosine Triphosphate, Signal transduction, Proto-Oncogene Proteins, Cell Division, Protein Binding, Signal Transduction, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Cell Nucleus/*metabolism/ultrastructure, Proto-Oncogene Proteins c-akt, Endosome, Endosomes, Protein Serine-Threonine Kinases, Biology, Histone Deacetylases, General Biochemistry, Genetics and Molecular Biology, Protein Binding/genetics, Endosomes/*metabolism/ultrastructure, 03 medical and health sciences, Cell Membrane/*metabolism/ultrastructure, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein-Serine-Threonine Kinases, rab5 GTP-Binding Proteins, 030304 developmental biology, Cell Nucleus, Binding Sites, Biochemistry, Genetics and Molecular Biology(all), Cell Membrane, Protein Transport/genetics, Cell Compartmentation, Microscopy, Electron, Guanosine Triphosphate/metabolism, Histone deacetylase complex, Signal Transduction/genetics, Carrier Proteins, 030217 neurology & neurosurgery, HeLa Cells |
| الوصف: | International audience; Signals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis. This pathway operates via APPL1 and APPL2, two Rab5 effectors, which reside on a subpopulation of endosomes. In response to extracellular stimuli such as EGF and oxidative stress, APPL1 translocates from the membranes to the nucleus where it interacts with the nucleosome remodeling and histone deacetylase multiprotein complex NuRD/MeCP1, an established regulator of chromatin structure and gene expression. Both APPL1 and APPL2 are essential for cell proliferation and their function requires Rab5 binding. Our findings identify an endosomal compartment bearing Rab5 and APPL proteins as an intermediate in signaling between the plasma membrane and the nucleus. |
| تدمد: | 0092-8674 1097-4172 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7d1003cd7cbcb1b3567790efdfb313Test https://doi.org/10.1016/s0092-8674Test(04)00117-5 |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f7d1003cd7cbcb1b3567790efdfb313 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00928674 10974172 |
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