In Vitro Assessment of Interaction Between Amino Acids and Copper in Neonatal Parenteral Nutrition
| العنوان: | In Vitro Assessment of Interaction Between Amino Acids and Copper in Neonatal Parenteral Nutrition |
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| المؤلفون: | Laurent Storme, Damien Lannoy, Aurélie Foinard, Christine Barthélémy, Pascal Odou, Florence Flamein, Ahmed Addad, Bertrand Décaudin, Marie-Adélaïde Bout, Maxime Perez |
| المصدر: | Journal of Parenteral and Enteral Nutrition. 40:827-834 |
| بيانات النشر: | Wiley, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Parenteral Nutrition, Chemical Phenomena, Energy dispersion, Medicine (miscellaneous), chemistry.chemical_element, 03 medical and health sciences, 0302 clinical medicine, Intensive Care Units, Neonatal, 030225 pediatrics, Chemical Precipitation, Humans, Cysteine, Amino Acids, chemistry.chemical_classification, Parenteral Nutrition Solutions, 030109 nutrition & dietetics, Nutrition and Dietetics, Chromatography, Spectrum Analysis, Infant, Newborn, Sulfur, Copper, In vitro, Amino acid, Membrane, Parenteral nutrition, chemistry, Microscopy, Electron, Scanning, Filtration |
| الوصف: | BACKGROUND: The repeated blackening of in-line filters has been observed during the infusion of parenteral nutrition 2-in-1 mixtures (binary parenteral nutrition [BPN]) delivered in a neonatal intensive care unit. This study aimed to examine the elemental content of precipitates isolated from infused BPN bags and determine the main physicochemical interactions occurring in these bags. MATERIALS AND METHODS: The infusion of BPN mixtures was simulated in vitro following hospital practices. Filter membranes were examined by scanning electron microscopy and energy dispersion spectroscopy (EDS). Amino acid (AA) profiles were obtained from BPN mixtures to determine the concentrations of each AA. RESULTS: Analyzed filter membranes revealed conglomerates of particles on filter surfaces. An EDS analysis generated spectra from isolated particles, identifying copper and sulfur as the major chemical elements. AA mean concentrations were relatively close to the expected value for each AA, except cysteine. Cysteine concentrations were very significantly lower than the expected values. CONCLUSION: A specific interaction was identified between 1 AA (cysteine) and a trace element (copper) in our BPN mixtures. |
| تدمد: | 1941-2444 0148-6071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f519f2b7f4fff009e7cbe57636f4d34Test https://doi.org/10.1177/0148607115571967Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2f519f2b7f4fff009e7cbe57636f4d34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19412444 01486071 |
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