DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19
| العنوان: | DNA and RNA Oxidative Damage and Mortality of Patients With COVID-19 |
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| المؤلفون: | Agustín F. González-Rivero, Nazario Ojeda, María M. Martín, A. Perez, Jordi Solé-Violán, Alejandro Jiménez, Juan J. Cáceres, Leonardo Lorente, Luis Ramos-Gómez, José Alberto Marcos Y Ramos, Antonia Pérez-Cejas |
| المصدر: | The American Journal of the Medical Sciences |
| بيانات النشر: | Southern Society for Clinical Investigation. Published by Elsevier Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Patients, Guanine, Oxidative phosphorylation, 030204 cardiovascular system & hematology, Gastroenterology, Disease-Free Survival, Oxidative damage, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Intensive care, Medicine, Humans, 030212 general & internal medicine, Clinical Investigation, Mortality, Aged, business.industry, SARS-CoV-2, RNA, COVID-19, General Medicine, DNA, DNA and RNA oxidative damage, Middle Aged, Prognosis, Icu admission, Survival Rate, chemistry, Spain, Female, business, Oxidation-Reduction, DNA Damage |
| الوصف: | Background Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) oxidative damage is associated with mortality of patients with different diseases. However, there are no data about DNA and RNA oxidative damage from coronavirus disease 2019 (COVID-19) patients. Thus, the objective of this study was to explore DNA and RNA oxidative damage in surviving and non-surviving COVID-19 patients. Materials and Methods Eight Intensive Care Units from 6 hospitals in the Canary Islands (Spain) participated in this prospective and observational study. We recorded the serum levels at ICU admission of the three guanine oxidized species (OGS) because guanine is the nucleobase that forms the DNA and RNA most prone to oxidation. Survival at 30 days was our end-point study. Results Non-surviving (n = 11) compared to surviving patients (n = 42) had higher APACHE-II (p |
| اللغة: | English |
| تدمد: | 1538-2990 0002-9629 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2b6070da4d2a777da6181b332b6655Test http://europepmc.org/articles/PMC7884223Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f2b6070da4d2a777da6181b332b6655 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15382990 00029629 |
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