Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1
| العنوان: | Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1 |
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| المؤلفون: | E. C. A. Mieke Houdijk, Dick Mul, Frank Brus, Agnes Clement-de Boers, M. Claire Woltering, Martine C. de Vries, Daniëlle C M van der Kaay, Johannes B. van Goudoever, Boudewijn Bakker, Marjolijn D. Akkermans |
| المساهمون: | Neonatology, Other departments, Amsterdam Gastroenterology Endocrinology Metabolism, Pediatric surgery, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), ACS - Diabetes & metabolism |
| المصدر: | Akkermans, M D, Houdijk, E C A M, Bakker, B, Clement-de Boers, A, van der Kaay, D C M, de Vries, M C, Woltering, M C, Mul, D, van Goudoever, J B & Brus, F 2018, ' Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1 ', European Journal of Pediatrics, vol. 177, no. 4, pp. 603-610 . https://doi.org/10.1007/s00431-018-3104-3Test European journal of pediatrics, 177(4), 603-610. Springer Verlag European Journal of Pediatrics, 177(4), 603-610. Springer Verlag |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Anemia, Iron, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, Hba1c level, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Prevalence, Medicine, Humans, In patient, Prospective Studies, Trial registration, Child, Netherlands, Glycated Hemoglobin, Anemia, Iron-Deficiency, business.industry, Iron deficiency, medicine.disease, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Female, Hemoglobin, Iron status, business |
| الوصف: | Children with diabetes mellitus (DM) type 1 may be at risk for iron deficiency (ID) although this has been little studied. ID is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. Unfortunately, absolute ID is often not distinguished from functional ID. Furthermore, iron-deficient anemia may influence hemoglobin A1c (HbA1c) levels. We aimed to determine the prevalence and type of ID and investigate its association with HbA1c levels in pediatric DM type 1 patients. We performed a two-center prospective observational study in which the iron status of Dutch children with DM type 1 was determined during a regular check-up. Absolute ID and functional ID were found in 13/227 (5.7%) and 100/214 (47%) patients, respectively, while only 15/113 (13%) patients also had anemia. HbA1c levels in patients with and without a deprived iron status (absolute or functional) were not significantly different (65 ± 17 vs. 65 ± 16 mmol/mol, p = 0.815). Functional, but not absolute, ID was common in Dutch pediatric DM type 1 patients. HbA1c levels were not associated with ID, which can be explained by the relatively mild deprived iron status in our patients. NTR4642 What is Known: • Iron deficiency is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. • Children with diabetes mellitus type 1 may be at risk for both types of iron deficiency and this can influence their hemoglobin A1c levels although this has been little studied. What is New: • In Dutch children with diabetes mellitus type 1, functional, but not absolute iron deficiency, is common and should not be treated with iron replacement therapy. • Hemoglobin A1c levels were not associated with iron deficiency, probably due to the relatively mild deprived iron status in our patients |
| اللغة: | English |
| تدمد: | 0340-6199 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1b5adfa5f0e634fd05e57a62c69814Test https://research.vumc.nl/en/publications/50862703-ca75-404f-9b24-1f4fd9188608Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....2f1b5adfa5f0e634fd05e57a62c69814 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03406199 |
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