Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression
| العنوان: | Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression |
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| المؤلفون: | Zhiliang Hu, Zhenwu Luo, Wei Jiang, Lisa Martin, Sonya L. Heath, Zhen Li, Hao Wu, Zhuang Wan, Lei Huang, Michael Kilby |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 1, p e0167640 (2017) |
| بيانات النشر: | Public Library of Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, RNA viruses, CD4-Positive T-Lymphocytes, Male, Cytotoxicity, Cell, lcsh:Medicine, HIV Infections, NK cells, CD38, Pathology and Laboratory Medicine, Toxicology, Lymphocyte Activation, 0302 clinical medicine, Immunodeficiency Viruses, Cellular types, Public and Occupational Health, 030212 general & internal medicine, lcsh:Science, Immune Response, Multidisciplinary, Membrane Glycoproteins, T Cells, Immune cells, Age Factors, Middle Aged, Vaccination and Immunization, 3. Good health, Killer Cells, Natural, medicine.anatomical_structure, Infectious Diseases, Anti-Retroviral Agents, Medical Microbiology, NK Cell Lectin-Like Receptor Subfamily K, Viral Pathogens, Viruses, White blood cells, Female, Pathogens, Natural killer cell activation, Research Article, Adult, Cell biology, Blood cells, Infectious Disease Control, T cell, Immunology, Cell Enumeration Techniques, Antiretroviral Therapy, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Immune system, Sex Factors, Antiviral Therapy, Lysosomal-Associated Membrane Protein 1, Retroviruses, medicine, Humans, Microbial Pathogens, Medicine and health sciences, Biology and life sciences, business.industry, lcsh:R, Lentivirus, Organisms, HIV, NKG2D, ADP-ribosyl Cyclase 1, CD4 Lymphocyte Count, 030104 developmental biology, Animal cells, Gene Expression Regulation, HIV-1, lcsh:Q, Preventive Medicine, business, Ex vivo |
| الوصف: | The role of natural killer (NK) cell function in HIV disease especially in the setting of long-term antiretroviral therapy (ART) and viral suppression is not fully understood. In the current study, we have investigated NK cell activation in healthy controls and aviremic ART-treated HIV+ subjects with different degrees of immune restoration. We performed a cross sectional study in 12 healthy controls and 24 aviremic ART-treated HIV-infected subjects including 13 HIV+ subjects with CD4+ T cells above 500 cells/μL defined as "immunologic responders" and 11 HIV+ subjects with CD4+ T cells below 350 cells/μL defined as "immunologic non-responders". We analyzed NK cell number, subset, and activation by expression of CD107a and NKG2D and co-expression of CD38 and HLA-DR. NK cell-mediated cytotoxicity against uninfected CD4+ T cells was tested in vitro. We found that NK cell absolute number, percentage of NK cells, and percentage of NK cell subsets were similar in the three study groups. The increased NK cell activation was found predominantly in CD56dimCD16+ subset of immunologic non-responders but not immunologic responders compared to healthy controls. The activation of NK cells was inversely correlated with the peripheral CD4+ T cell count in HIV+ subjects, even after controlling for chronic T cell activation, sex, and age, potential contributors for CD4+ T cell counts in HIV disease. Interestingly, NK cells from immunologic non-responders mediated cytotoxicity against uninfected CD4+ T cells ex vivo. NK cells may play a role in blunted CD4+ T cell recovery in ART-treated HIV disease. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eefa32922e7d876b04a805b84bfd613Test http://europepmc.org/articles/PMC5226712Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2eefa32922e7d876b04a805b84bfd613 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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