Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment
| العنوان: | Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment |
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| المؤلفون: | Stephanie O. Breukink, Martijn J.L. Bours, José J.L. Breedveld-Peters, Eline H. van Roekel, Jody van den Ouweland, Fränzel J.B. Van Duijnhoven, Janna L. Koole, Eric T.P. Keulen, Matty P. Weijenberg, Maryska L.G. Janssen-Heijnen |
| المساهمون: | Epidemiologie, RS: GROW - R1 - Prevention, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9) |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29 (2020) 6 Cancer Epidemiology Biomarkers & Prevention, 29(6), 1135-1144. American Association for Cancer Research Inc. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(6), 1135-1144 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, D SUPPLEMENTATION, Time Factors, Nutrition and Disease, Epidemiology, Colorectal cancer, QUESTIONNAIRE, HOSPITAL ANXIETY, Hospital Anxiety and Depression Scale, DIAGNOSIS, 03 medical and health sciences, D DEFICIENCY, 0302 clinical medicine, Cancer Survivors, Quality of life, Internal medicine, HEALTH-RELATED QUALITY, Voeding en Ziekte, Vitamin D and neurology, Humans, Medicine, Life Science, Longitudinal Studies, Vitamin D, Stage (cooking), Fatigue, Depression (differential diagnoses), METAANALYSIS, Aged, VLAG, business.industry, CHEMOTHERAPY, medicine.disease, DEPRESSION, DYSFUNCTIONS, humanities, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Anxiety, Female, medicine.symptom, Colorectal Neoplasms, business, Blood sampling |
| الوصف: | Background: Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer survivors. The current study investigated longitudinal associations between serum 25-hydroxyvitamin D3 (25OHD3) concentrations and quality of life in stage I–III colorectal cancer survivors up to 2 years after treatment. Methods: Patients with colorectal cancer (n = 261) were included upon diagnosis. Home visits (including blood sampling) were performed at diagnosis and at 6 weeks, 6 months, 1 year, and 2 years after treatment. Serum 25OHD3 concentrations were measured using LC/MS-MS and adjusted for season. Validated questionnaires were used to assess global quality of life and cognitive functioning (EORTC-QLQ-C30), fatigue (EORTC-QLQ-C30 and Checklist Individual Strength, CIS), and depression and anxiety (Hospital Anxiety and Depression Scale). Statistical analyses were performed using linear mixed models and adjusted for sex, age, time since diagnosis, therapy, comorbidities, physical activity, and body mass index. Results: At diagnosis, 45% of patients were vitamin D deficient ( Conclusions: Higher concentrations of 25OHD3 were longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors. Impact: This study suggests that higher 25OHD3 concentrations may be beneficial for colorectal cancer survivors. Future intervention studies are needed to corroborate these findings. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1055-9965 1135-1144 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e70c0625db845b23b2c413102ee53fcTest https://doi.org/10.1158/1055-9965.epi-19-1522Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e70c0625db845b23b2c413102ee53fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10559965 11351144 |
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