Clinical significance of chemokine receptor antagonists
| العنوان: | Clinical significance of chemokine receptor antagonists |
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| المؤلفون: | Guangdi Li, Erik De Clercq, Miao Miao |
| المصدر: | Expert Opinion on Drug Metabolism & Toxicology. 16:11-30 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Receptors, CXCR4, CCR2, Chemokine, Receptors, CCR4, Receptors, CCR5, Receptors, CCR2, CCR4, CCR5 receptor antagonist, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, CXCR4, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Drug Development, Mogamulizumab, Animals, Humans, Medicine, CXCR4 antagonist, biology, business.industry, General Medicine, 030220 oncology & carcinogenesis, biology.protein, Receptors, Chemokine, business, medicine.drug |
| الوصف: | Introduction: Chemokine receptors are important therapeutic targets for the treatment of many human diseases. This study will provide an overview of approved chemokine receptor antagonists and promising candidates in advanced clinical trials.Areas covered: We will describe clinical aspects of chemokine receptor antagonists regarding their clinical efficacy, mechanisms of action, and re-purposed applications.Expert opinion: Three chemokine antagonists have been approved: (i) plerixafor is a small-molecule CXCR4 antagonist that mobilizes hematopoietic stem cells; (ii) maraviroc is a small-molecule CCR5 antagonist for anti-HIV treatment; and (iii) mogamulizumab is a monoclonal-antibody CCR4 antagonist for the treatment of mycosis fungoides or Sezary syndrome. Moreover, phase 3 trials are ongoing to evaluate many potent candidates, including CCR5 antagonists (e.g. leronlimab), dual CCR2/CCR5 antagonists (e.g. cenicriviroc), and CXCR4 antagonists (e.g. balixafortide, mavorixafor, motixafortide). The success of chemokine receptor antagonists depends on the selective blockage of disease-relevant chemokine receptors which are indispensable for disease progression. Although clinical translation has been slow, antagonists targeting chemokine receptors with multifaced functions offer the potential to treat a broad spectrum of human diseases. |
| تدمد: | 1744-7607 1742-5255 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6ccb11ad32542a99ebb3d97086dde5Test https://doi.org/10.1080/17425255.2020.1711884Test |
| رقم الانضمام: | edsair.doi.dedup.....2e6ccb11ad32542a99ebb3d97086dde5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447607 17425255 |
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