Dynamics of pseudo‐atrophy in RRMS reveals predominant gray matter compartmentalization
| العنوان: | Dynamics of pseudo‐atrophy in RRMS reveals predominant gray matter compartmentalization |
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| المؤلفون: | Maria Pia Sormani, Antonio Giorgio, Giordano Gentile, Andrea Visconti, Marco Battaglini, Claudio Gasperini, Maria Laura Stromillo, Rosa Cortese, Nicola De Stefano |
| المصدر: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 8, Iss 3, Pp 623-630 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Multiple Sclerosis, Atrophy, Double-Blind Method, Female, Gray Matter, Humans, Immunologic Factors, Interferon beta-1a, Magnetic Resonance Imaging, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, White Matter, Neurosciences. Biological psychiatry. Neuropsychiatry, Relapsing-Remitting, Placebo, Gastroenterology, White matter, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, In patient, RC346-429, Research Articles, medicine.diagnostic_test, business.industry, General Neuroscience, Multiple sclerosis, Magnetic resonance imaging, medicine.disease, Clinical trial, 030104 developmental biology, medicine.anatomical_structure, Neurology. Diseases of the nervous system, Neurology (clinical), Volume loss, business, 030217 neurology & neurosurgery, RC321-571, Research Article |
| الوصف: | Objective To assess the dynamics of “pseudo‐atrophy,” the accelerated brain volume loss observed after initiation of anti‐inflammatory therapies, in patients with multiple sclerosis (MS). Methods Monthly magnetic resonance imaging (MRI) data of patients from the IMPROVE clinical study (NCT00441103) comparing relapsing‐remitting MS patients treated with interferon beta‐1a (IFNβ‐1a) for 40 weeks versus those receiving placebo (16 weeks) and then IFNβ‐1a (24 weeks) were used to assess percentage of gray (PGMVC) and white matter (PWMVC) volume changes. Comparisons of PGMVC and PWMVC slopes were performed with a mixed effect linear model. In the IFNβ‐1a‐treated arm, a quadratic term was included in the model to evaluate the plateauing effect over 40 weeks. Results Up to week 16, PGMVC was −0.14% per month in the placebo and −0.27% per month in treated patients (P |
| تدمد: | 2328-9503 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e22cd13bd04b59515b00dabd0a5005dTest https://doi.org/10.1002/acn3.51302Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e22cd13bd04b59515b00dabd0a5005d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23289503 |
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