Echinocandins: Are They All The Same?
| العنوان: | Echinocandins: Are They All The Same? |
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| المؤلفون: | Mahmoud A. Ghannoum, Pranab K. Mukherjee, L. Puzniak, Daniel J. Sheehan, H. Schlamm |
| المصدر: | Journal of Chemotherapy. 23:319-325 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pharmacology, Antifungal, Antifungal Agents, medicine.drug_class, business.industry, Micafungin, bacterial infections and mycoses, Food and drug administration, Echinocandins, chemistry.chemical_compound, Infectious Diseases, Mycoses, Oncology, chemistry, polycyclic compounds, medicine, Animals, Humans, Anidulafungin, Pharmacology (medical), Caspofungin, business, medicine.drug |
| الوصف: | The discovery of echinocandins, and their development and approval, was hailed as a significant addition to our antifungal armamentarium, previously predominated by polyenes and azoles. To date, three echinocandins (anidulafungin, caspofungin, and micafungin) have been approved by the U.S. Food and Drug Administration for the treatment of fungal infections. Since all three echinocandins target the fungal cell wall and share a similar structural chemical backbone, they are perceived to be identical. However, a scientific literature review shows distinct differences among the echinocandins in terms of in vitro activity, fungicidal activity, post-antifungal effect, paradoxical effect, and activity on biofilms. More investigation is warranted to determine if the observed differences among the echinocandins can translate to clinical advantages. |
| تدمد: | 1973-9478 1120-009X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd14588de063e99d26531e7ea7810b6Test https://doi.org/10.1179/joc.2011.23.6.319Test |
| رقم الانضمام: | edsair.doi.dedup.....2dd14588de063e99d26531e7ea7810b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19739478 1120009X |
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