Urinary excretion of retinol-binding protein in type 1 (insulin-dependent) diabetic patients with microalbuminuria and clinical diabetic nephropathy
| العنوان: | Urinary excretion of retinol-binding protein in type 1 (insulin-dependent) diabetic patients with microalbuminuria and clinical diabetic nephropathy |
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| المؤلفون: | P. Ondrejka, Torsten Deckert, P. Pontuch, Tonny Jensen, M. Mikulecky |
| المصدر: | Acta Diabetologica. 28:206-210 |
| بيانات النشر: | Springer Science and Business Media LLC, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Renal function, Excretion, Diabetic nephropathy, Endocrinology, Reference Values, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Sex Characteristics, business.industry, General Medicine, medicine.disease, Retinol-Binding Proteins, Retinol binding protein, Diabetes Mellitus, Type 1, Creatinine, Metabolic control analysis, Female, Microalbuminuria, medicine.symptom, business |
| الوصف: | The urinary excretion of retinol-binding protein (RBP) was studied in 101 insulin-dependent diabetic patients allocated to three groups according to 24-h urinary albumin excretion rate (UAE) (median of three urine collections): group 1 (n = 45), normal UAE less than 30 mg/24 h; group 2 (n = 27), microalbuminuria (UAE 30-300 mg/24 h); and group 3 (n = 29), clinical diabetic nephropathy (UAE greater than 300 mg/24 h). We used 23 healthy subjects as controls. Fractional clearance of RBP (FC-RBP) and its 24-h urinary excretion rate (URBP) were higher in each diabetic group than in healthy subjects, the highest values being found in group 3. Groups 1 and 2 did not differ in URBP and FC-RBP. There was a correlation between FC-RBP and haemoglobin A1c in both the total diabetic cohort (P less than 0.001) and in diabetic patients in groups 1 and 2 with a glomerular filtration rate of more than 90 ml/min (P less than 0.05). No correlation was found between FC-RBP and UAE and/or duration of diabetes in any of the diabetic groups. We conclude that the increased urinary excretion of RBP, indicating proximal tubular dysfunction, is already present in normoalbuminuric insulin-dependent diabetic patients and correlates with metabolic control. Further deterioration in proximal tubular function was not observed in microalbuminuric patients, but is a late event in clinical diabetic nephropathy. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc9f2fe36dbce37bcbe75a41f482adaTest https://doi.org/10.1007/bf00779000Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2dc9f2fe36dbce37bcbe75a41f482ada |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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