Body mass index trajectories and prostate cancer risk: Results from the EPICAP study
| العنوان: | Body mass index trajectories and prostate cancer risk: Results from the EPICAP study |
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| المؤلفون: | Florence Menegaux, Emilie Cordina Duverger, Fanny Artaud, C Lavalette, Brigitte Trétarre, Sylvie Cénée, Pierre-Jean Lamy, Xavier Rebillard |
| المساهمون: | Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Clinique Beau Soleil [Montpellier], Labosud, Registre des Tumeurs de l'Hérault, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES Fondation de France Ligue Contre le Cancer Centre hospitalier universitaire Sainte-Justine, CHUSJ Ligue Contre le Cancer, The authors thank the clinical research nurses who were in charge of participants' interview, anthropometric measurements and biological sample collection (Anne-Laure Astolfi, Coline Bernard, Oriane Boyer, Marie-H?l?ne De Campo, Sandrine Margaroli, Louise N'Diaye, Sabine Perrier-Bonnet). The authors also thank Christian Prad and Nadine Soller for help with patient medical data collection within the H?rault Cancer Registry (Registre des tumeurs de l'H?rault, Montpellier, France). The authors thank the EPICAP study Group: Urologists: Drs Didier Ayuso, Bruno Segui (Centre Hospitalier Bassin de Thau, S?te, France), Alain Guillaume, Jean-Paul Constans, Olivier Delbos, Pierre Lanfray, Damien Rizet, Etienne Cu?nant?(Cabinet Urologie du Polygone, Montpellier, France), Michel?Locci (Centre Hospitalier, B?ziers, France), Etienne Cu?nant?(Clinique Ste Th?r?se, S?te, France), Nicolas Drianno, Bernard Marc, Paulo Soares (Polyclinique Saint Privat, B?ziers, France), Antoine Faix, Samer Abdel Hamid, Bruno Segui (Service urologie, Clinique Beau Soleil, Montpellier, France), Samer Abdel Hamid (Clinique Saint Louis, Ganges, France), Laurent Cabaniols, Maxime Robert, Rodolphe Thuret (Centre Hospitalo-Universitaire, H?pital Lapeyronie, Montpellier, France). Pathologists: Drs Didier Brel, Lysiane Schweizer, Philippe Nayraud, C. Lecam-Savin (B?ziers), Roland Daniel, Jean Baptiste Perdigou, Chantal Compan, Mireille Granier, Jean Louis Bouzigues, Elisabeth Broquerie, Jo?lle Simony, Fr?d?ric Bibeau, Pierre Baldet, Isabelle Serre (Montpellier), Marie Laure Gaume (S?te). Biologists: Drs Montels (Service de Biologie M?dicale, Institut du Cancer de Montpellier, Montpellier, France), Dumas (B?ziers, France), Buono (S?te, France), Bonnefille (Lodeve, France), Ruiz (Lunel, France), Paleirac (Clermont-l'H?rault, France). Finally, the authors thank Dr Alexis Elbaz, CESP-INSERM Team Exposome, Heredity, Cancer and Health, for his help on BMI trajectories analyses. The EPICAP study was funded by Ligue nationale contre le cancer, Ligue contre le cancer du Val de Marne, Fondation de France, Agence nationale de s?curit? sanitaire de l'alimentation, de l'environnement et du travail (ANSES). The first author, C?line Lavalette, is funded by a 3-year doctoral allowance from the Paris-Saclay University, for her PhD. |
| المصدر: | Cancer Medicine Cancer Medicine, Wiley, 2020, 9 (17), pp.6421-6429. ⟨10.1002/cam4.3241⟩ Cancer Medicine, Vol 9, Iss 17, Pp 6421-6429 (2020) |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Risk, Cancer Research, medicine.medical_specialty, obesity, [SDV]Life Sciences [q-bio], body mass index, Overweight, lcsh:RC254-282, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Original Research, Aged, 2. Zero hunger, Prostate cancer risk, business.industry, Incidence, Age Factors, Prostatic Neoplasms, nutritional and metabolic diseases, weight gain, Non-Smokers, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, prostate cancer, Obesity, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, Case-Control Studies, trajectory, Life course approach, France, medicine.symptom, business, Body mass index, Weight gain, Cancer Prevention |
| الوصف: | Elevated body mass index (BMI) has been inconsistently associated with prostate cancer occurrence but it has been suggested that life course adulthood obesity may be associated with an increased risk of prostate cancer. However, few studies have investigated lifetime BMI and prostate cancer risk. We analyzed life course BMI trajectories on prostate cancer risk based on data from the Epidemiological study of Prostate Cancer (EPICAP). We included in our analyses 781 incident prostate cancer cases and 829 controls frequency matched by age. Participants were asked about their weight every decade from age 20 to two years before reference date. BMI trajectories were determined using group‐based trajectory modeling to identify groups of men with similar patterns of BMI changes. We identified five BMI trajectories groups. Men with a normal BMI at age 20 developing overweight or obesity during adulthood were at increased risk of aggressive prostate cancer compared to men who maintained a normal BMI. Our results suggest that BMI trajectories resulting in overweight or obesity during adulthood are associated with an increased risk of aggressive prostate cancer, particularly in never smokers, emphasizing the importance of maintaining a healthy BMI throughout adulthood. The influence of body weight during lifetime on PCa risk remains largely ununderstood and has been poorly investigated. Our findings suggest that elevated BMI during adulthood resulting in overweight or obesity is associated with an increased risk of aggressive PCa, emphasizing the importance of maintaining a healthy BMI throughout adulthood. |
| اللغة: | English |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc7e0c8c91c46bb32ce483f5b1ec427Test https://hal.archives-ouvertes.fr/hal-03032361Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2dc7e0c8c91c46bb32ce483f5b1ec427 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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