Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children
| العنوان: | Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children |
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| المؤلفون: | Sihem Benaboud, Jean-Marc Tréluyer, Saik Urien, Julie Toubiana, Mathieu Genuini, Claire Heilbronner, Déborah Hirt, Radia Aboura, Sylvain Renolleau, Mehdi Oualha, Agathe Béranger |
| المصدر: | Clinical Pharmacokinetics. 57:867-875 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Cefotaxime, Adolescent, Critical Illness, 030106 microbiology, Population, law.invention, 03 medical and health sciences, Randomized controlled trial, Pharmacokinetics, law, Humans, Medicine, Pharmacology (medical), Prospective Studies, Dosing, Child, education, Pharmacology, Volume of distribution, Pediatric intensive care unit, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Infant, Bacterial Infections, Models, Theoretical, Anti-Bacterial Agents, Surgery, Child, Preschool, Anesthesia, Female, Median body, business, medicine.drug |
| الوصف: | During sepsis, optimal plasma antibiotic concentrations are mandatory. Modifications of pharmacokinetic parameters could lead to low drug concentrations and therefore, insufficient therapeutic levels. The aim of this study was to build a population pharmacokinetic model for cefotaxime and its metabolite desacetylcefotaxime in order to optimize individual dosing regimens for critically ill children. All children aged |
| تدمد: | 1179-1926 0312-5963 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4bd11ef7623a4bb829fb7e7ceaf2f8Test https://doi.org/10.1007/s40262-017-0602-9Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2d4bd11ef7623a4bb829fb7e7ceaf2f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11791926 03125963 |
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