Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study
| العنوان: | Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study |
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| المؤلفون: | Yoshinori Hasegawa, Momokazu Gotoh, Takayuki Okuji, Hiroshi Takagi, Yasuhiro Kodera, Eri Wada, Masahiko Ando, Masato Nagino, Taku Tsunekawa, Hideharu Hibi, Masashi Akiyama, Yoshihiro Ito, Takeshi Onoue, Daisuke Hagiwara, Naozumi Hashimoto, Mariko Sugiyama, Tomoko Kobayashi, Mitsuro Kanda, Motomitsu Goto, Mitsuhiro Fujishiro, Masahiro Morise, Hidetaka Suga, Michihiko Sone, Kenji Yokota, Hitoshi Kiyoi, Tetsunari Hase, Yuichi Ando, Yasushi Fujimoto, Yoshinori Yasuda, Norio Okada, Hiroshi Arima, Ryoichi Banno, Shintaro Iwama |
| المصدر: | British Journal of Cancer |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, endocrine system, Thyroiditis, endocrine system diseases, Programmed Cell Death 1 Receptor, Thyroid Gland, 030209 endocrinology & metabolism, Autoimmunity, Predictive markers, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Thyroid dysfunction, Risk Factors, Internal medicine, Medicine, Humans, Cumulative incidence, Prospective Studies, Prospective cohort study, Aged, Ultrasonography, Aged, 80 and over, biology, business.industry, Thyroid, Middle Aged, medicine.disease, Anti-thyroid autoantibodies, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, biology.protein, Female, Antibody, Thyroid function, business |
| الوصف: | Background Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction. However, no predictive biomarkers enabling stratification of thyroid dysfunction risk have been identified. Methods A total of 209 patients treated with an anti-PD-1 antibody were evaluated for anti-thyroid antibodies at baseline and prospectively for thyroid function every 6 weeks for 24 weeks after treatment initiation, and then observed until the visits stopped. Thyroid ultrasonography was performed if the patient was positive for anti-thyroid antibodies at baseline. Results Of the 209 patients, 19 (9.1%) developed thyroid dysfunction (destructive thyroiditis or hypothyroidism). The cumulative incidence of thyroid dysfunction was significantly higher in patients who were positive vs. negative for anti-thyroid antibodies (15/44 [34.1%] vs. 4/165 [2.4%], p p = 0.001). None of the patients developed thyroid dysfunction after the initial 24-week period. Conclusions The risk of thyroid dysfunction induced by anti-PD-1 antibodies can be predicted by evaluation of anti-thyroid antibodies and the thyroid echo pattern at baseline. Trial registration UMIN000019024. |
| تدمد: | 1532-1827 0000-1902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d435b08afb11dbbc10da438ec3367abTest https://pubmed.ncbi.nlm.nih.gov/32009131Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d435b08afb11dbbc10da438ec3367ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00001902 |
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