Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning
| العنوان: | Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning |
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| المؤلفون: | Jinyi Lan, Lei Ren, Yifan Wei, Lina Gao, Bo Liu, Annan Chen |
| المصدر: | PLoS ONE PLoS ONE, Vol 14, Iss 9, p e0222521 (2019) |
| بيانات النشر: | Public Library of Science, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Anti-Inflammatory Agents, Phenylalanine, Pharmacology, Pathology and Laboratory Medicine, Biochemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Paraquat, Drug Metabolism, Malondialdehyde, Medicine and Health Sciences, Metabolites, Immune Response, Lung, Protein Metabolism, chemistry.chemical_classification, Multidisciplinary, biology, Poisoning, Lung Injury, Enzymes, Chemistry, Dismutases, 030220 oncology & carcinogenesis, Physical Sciences, Medicine, Metabolic Pathways, Research Article, Nicotine, Science, Immunology, Acute Lung Injury, Pulmonary Edema, Lung injury, Superoxide dismutase, 03 medical and health sciences, Signs and Symptoms, Alkaloids, Diagnostic Medicine, Lactate dehydrogenase, Animals, Metabolomics, Pharmacokinetics, Inflammation, Reactive oxygen species, Nicotinamide, L-Lactate Dehydrogenase, Superoxide Dismutase, Tumor Necrosis Factor-alpha, Hydantoins, Chemical Compounds, Biology and Life Sciences, Proteins, 030104 developmental biology, Metabolism, chemistry, biology.protein, Enzymology |
| الوصف: | Paraquat (PQ), one of the most widely used herbicides worldwide, causes severe toxic effects in humans and animals. 1-methylhydantoin (MH) is an active ingredient of Ranae Oviductus, which has broad pharmacological activities, e.g., eliminating reactive oxygen species and inhibiting inflammation. This study investigated the effects of MH on lung injury induced by PQ. A PQ poisoning model was established by intragastric infusion of PQ (25 mg/kg), and the control group was simultaneously gavaged with the same dose of saline. The MH group was intraperitoneally injected with 100 mg/kg once per day after intragastric infusion of PQ (25 mg/kg) for five consecutive days. All animals were sacrificed on the sixth day, and the lung tissues were dissected for metabolomics analysis. The lactate dehydrogenase (LDH) activity, superoxide dismutase (SOD) activity, TNF-α and malondialdehyde (MDA) content were determined according to the instructions of the detection kit. Compared with that in the control group, the content of LDH, TNF-α and MDA in the lung tissue of the PQ group was significantly higher, and the activity of SOD in the lung tissue was significantly lower (all p 0.05). There were significant differences in MDA and TNF-α content between the PQ group and MH group (all p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf208f421c9446121c92dcdc3eca018Test http://europepmc.org/articles/PMC6764654Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2cf208f421c9446121c92dcdc3eca018 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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