High incidence of falls in patients with myotonic dystrophy type 1 and 2: A prospective study
| العنوان: | High incidence of falls in patients with myotonic dystrophy type 1 and 2: A prospective study |
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| المؤلفون: | Fran H.P. Smulders, A.A. Tieleman, Joost Raaphorst, Joost Berends, Baziel G.M. van Engelen, Nicol C. Voermans, Corinne G.C. Horlings |
| المساهمون: | Neurology, Amsterdam Neuroscience - Neurodegeneration |
| المصدر: | Neuromuscular Disorders, 29, 758-765 Neuromuscular disorders, 29(10). Elsevier Limited Neuromuscular Disorders, 29, 10, pp. 758-765 |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, musculoskeletal diseases, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Myotonic dystrophy, Head trauma, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, medicine, Humans, Myotonic Dystrophy, Clinical significance, Prospective Studies, Prospective cohort study, Genetics (clinical), Balance (ability), Muscle Weakness, business.industry, Incidence (epidemiology), Age Factors, Muscle weakness, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, 030104 developmental biology, Neurology, Pediatrics, Perinatology and Child Health, Accidental Falls, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Fall prevention |
| الوصف: | We aimed to examine the incidence as well as the circumstances and the consequences of falling in adult patients with myotonic dystrophy type 1 and 2 (DM1/DM2). We performed a prospective cohort study in 209 subjects, of which 102 had DM1, 42 had DM2 and 65 healthy controls. An assessment of their falls was carried out during 100 consecutive days. In addition, falls during the previous year were reported. The primary outcome measure was the number of self-reported falls per participant during these 100 days. The secondary outcome measures included self-reported causes, circumstances and consequences of the falls. Mean (SD) falls per participant in 100 days was seven- to eightfold higher in patients with DM1 (0.74 (0.14)) and DM2 (0.62 (0.20)) compared to the controls (0.09 (0.04); p < 0.001)). Sixteen percent of DM1 and 17% of DM2 patients fell at least twice. Two-thirds of the falls occurred inside. Fifty percent of falls resulted in an injury, including a head trauma in four patients. Compared to non-fallers, those patients who fell were older (DM1/DM2), had a lower DM1-Activ score (DM1), had more muscle weakness (DM1), and reported less confidence in balance (DM1). This study demonstrates a high incidence and clinical relevance of falling in patients with DM1 and DM2. Fall prevention strategies in both DM1 and DM2 should focus on adaptations of the home environment and the patient's interaction in this environment. |
| وصف الملف: | application/pdf |
| تدمد: | 0960-8966 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb2fd0c47cacebd58209292dda3a297Test https://doi.org/10.1016/j.nmd.2019.08.012Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2cb2fd0c47cacebd58209292dda3a297 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09608966 |
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