Efficacy of liposomal amphotericin against febrile neutropenia in pediatric patients receiving prophylactic voriconazole
| العنوان: | Efficacy of liposomal amphotericin against febrile neutropenia in pediatric patients receiving prophylactic voriconazole |
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| المؤلفون: | Takaaki Nakano, Daisuke Suzuki, Kunihiko Kobayashi, Ryoji Kobayashi, Hirozumi Sano, Satoru Matsushima, Daiki Hori, Kouya Kodama, Kenji Kishimoto, Masato Yanagi |
| المصدر: | Pediatrics International. 63:550-555 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Antifungal Agents, Adolescent, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Amphotericin B, 030225 pediatrics, Internal medicine, medicine, Humans, In patient, Child, Febrile Neutropenia, Voriconazole, business.industry, Infant, Myeloid leukemia, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, Hematological Diseases, Antibacterial therapy, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Liposomal amphotericin, business, Febrile neutropenia, medicine.drug |
| الوصف: | BACKGROUND The risk factors for invasive fungal infection have gradually become evident for pediatric patients with hematological diseases. Here we analyze the efficacy of liposomal amphotericin (L-AMB) for pediatric patients with febrile neutropenia using prophylactic voriconazole (VRCZ). METHOD We administered L-AMB (2.5 mg/kg/day) in patients with febrile neutropenia who were receiving prophylactic VRCZ (10 mg/kg/day, orally) and were resistant to second-line antibiotics therapy. Thirteen patients (5 males, 8 females) with 19 febrile neutropenia episodes were targeted in this analysis. The median age of the patients was 14 years (range, 1-19 years). Eighteen out of 19 episodes occurred in patients with acute myeloid leukemia, with the remaining episode occurring in a patient with acute unclassified leukemia. RESULTS The median period from start of L-AMB administration to resolution of fever was 4 days (1-27 days). In 15 out of 19 episodes, fever resolved within 5 days from commencement of L-AMB administration. Using criteria proposed by T. J. Walsh et al., the success rate of L-AMB for febrile neutropenia was 89.5% in this study. CONCLUSIONS Although the sample size of our study was small, the extremely high efficacy of L-AMB warrants its administration in patients with febrile neutropenia who are receiving VRCZ. |
| تدمد: | 1442-200X 1328-8067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9ad02cd7e715ea2178c632c2671dc9Test https://doi.org/10.1111/ped.14450Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2c9ad02cd7e715ea2178c632c2671dc9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1442200X 13288067 |
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