Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from a cohort study
| العنوان: | Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from a cohort study |
|---|---|
| المؤلفون: | Josine C. van der Heyden, Sarah A. Bovenberg, Dick Mul, Erwin Birnie, Henk J. Veeze, Henk-Jan Aanstoot |
| المساهمون: | Pediatrics, Health Psychology Research (HPR) |
| المصدر: | BMC Endocrine Disorders, 16. BioMed Central Ltd. BMC Endocrine Disorders Bmc endocrine disorders, 16:49. BMC |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Male, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Pediatrics, Cohort Studies, Skin autofluorescence, 0302 clinical medicine, Risk Factors, Glycation, GLYCEMIC CONTROL, 030212 general & internal medicine, OXIDATIVE STRESS, Child, Skin, COMPLICATIONS, integumentary system, Optical Imaging, Skin advanced glycation end products, General Medicine, Type 1 diabetes, Female, Research Article, Cohort study, Adult, medicine.medical_specialty, END-PRODUCTS, Adolescent, 030209 endocrinology & metabolism, Diabetic complications, 03 medical and health sciences, AGE, Optical imaging, SDG 3 - Good Health and Well-being, Internal medicine, Diabetes mellitus, medicine, Humans, FLUORESCENCE, ACCUMULATION, Glycated Hemoglobin, ADVANCED GLYCATION ENDPRODUCTS, business.industry, MORTALITY, fungi, medicine.disease, DYSFUNCTION, Advanced Glycation Endproducts, Surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Early Diagnosis, Multivariate Analysis, Linear Models, business, Biomarkers |
| الوصف: | Background Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (SAF) as a potential surrogate risk marker. Methods This study included a cross-sectional analysis of SAF in 77 patients with type 1 diabetes mellitus and 118 healthy controls across age categories (11–12, 13–14, 15–16, and 17–19 years old). In patients, the impact of current and historical glycated hemoglobin (HbA1c) values, age, and duration of diabetes on SAF was studied in a retrospective cohort study and analyzed with multivariable analyses. Results SAF was significantly and similarly higher in patients when compared with controls across all age categories (P ≤0.009). For patients, age, duration of diabetes, and current and historical HbA1c were associated with SAF in univariate analysis. Multivariate analysis showed no association between HbA1c and SAF. A subgroup of patients with a HbA1c-within-target (≤7.5 %/59 mmol/mol) were observed to have high SAF. Conclusion Children and adolescents with type 1 diabetes show higher SAF than controls. The presumed correlation of high HbA1c with high SAF does not exist in all patients. Thus, use of this non-invasive measure may provide a surrogate marker for diabetic complications, additional to HbA1c. |
| وصف الملف: | application/pdf |
| تدمد: | 1472-6823 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c91802b69ef03a3563929e8b6159ddfTest https://doi.org/10.1186/s12902-016-0129-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c91802b69ef03a3563929e8b6159ddf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14726823 |
|---|