The prevalence of human T‐lymphotropic virus type 1 & 2 (HTLV‐1/2) in South African blood donors
| العنوان: | The prevalence of human T‐lymphotropic virus type 1 & 2 (HTLV‐1/2) in South African blood donors |
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| المؤلفون: | Ravi Reddy, Edward L. Murphy, Jabulisile Jaza, Olivier Cassar, Antoine Gessain, Charlotte Ingram, Marion Vermeulen, Charl Coleman, Colwyn Poole, Genevieve Jacobs, Wendy Sykes, Brian Custer, Zhanna Kaidarova, Carol Hlela |
| المساهمون: | South African National Blood Service (SANBS), Vitalant Research Institute [San Francisco], University of California [San Francisco] (UCSF), University of California, Red Cross Children's Hospital [Cape Town, South Africa], Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), We would like to thank Vitalant Research Institute for partial funding and Abbott Diagnostics for providing a portion of the HTLV test kits. A special thanks to all the Donation Testing staff at SANBS for performing the testing in addition to their normal work. We would also like to thank Dr. Diana Hardie of the South African National Health Laboratory Service for performing the HTLV proviral DNA testing for confirmation of the Inno‐LIA results., University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) |
| المصدر: | Vox Sanguinis Vox Sanguinis, Wiley, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩ Vox sanguinis, vol 114, iss 5 Vox Sang Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; et al.(2019). The prevalence of human T-lymphotropic virus type 1 & 2 (HTLV-1/2) in South African blood donors.. Vox sanguinis. doi: 10.1111/vox.12778. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7582w44xTest Vox Sanguinis, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, [SDV]Life Sciences [q-bio], Medical Physiology, Blood Donors, 030204 cardiovascular system & hematology, Human T-lymphotropic virus, Serology, Blood donations, South Africa, 0302 clinical medicine, MESH: South Africa, Seroepidemiologic Studies, Epidemiology, Prevalence, Mass Screening, donors, education.field_of_study, Human T-lymphotropic virus 1, MESH: Middle Aged, biology, Human T-lymphotropic virus 2, Blood Screening, Hematology, General Medicine, Middle Aged, 3. Good health, MESH: Young Adult, Female, MESH: HTLV-II Infections, Adult, medicine.medical_specialty, Adolescent, Population, Clinical Sciences, serological testing, Article, 03 medical and health sciences, Young Adult, MESH: HTLV-I Infections, medicine, Seroprevalence, Humans, MESH: Mass Screening, education, MESH: Prevalence, MESH: Adolescent, MESH: Seroepidemiologic Studies, MESH: Human T-lymphotropic virus 1, MESH: Humans, MESH: Human T-lymphotropic virus 2, business.industry, MESH: Blood Donors, MESH: Adult, Odds ratio, biology.organism_classification, HTLV-I Infections, MESH: Male, Cardiovascular System & Hematology, HTLV-II Infections, business, MESH: Female, 030215 immunology, Demography, transfusion - transmissible infections |
| الوصف: | Author(s): Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; Kaidarova, Zhanna; Hlela, Carol; Gessain, Antoine; Cassar, Olivier; Poole, Colwyn; Ingram, Charlotte; Murphy, Edward L; Reddy, Ravi | Abstract: Background and objectivesDonated blood is not currently screened for human T-cell lymphotropic virus (HTLV) in South Africa. Several small studies have detected HTLV-1 in South Africa, but prevalence by geographic region or population group is unavailable.Materials and methodsWe performed a large seroprevalence study of South African blood donors during 3 months in 2013. All geographic regions except the Western Cape were included, and Black and Coloured (local term for mixed race) donors were oversampled. Identity-unlinked plasma samples were screened with the Abbott Prism HTLV-1/2 assay, and repeatedly reactive samples were tested by the Inno-LIA HTLV-1/2 Score confirmatory assay. Odds ratios were calculated with multivariable logistic regression.ResultsOf 46 752 donors tested, 133 (0·28%) were initially reactive, 111 (0·24%) repeatedly reactive and 57 (0·12%) confirmed positive for HTLV-1; none were HTLV-2 positive. Prevalence was 0·062% weighted to annual blood donations but highly concentrated in the Black population group (OR = 20·24 CI: 2·77-147·88); higher in females than males (OR = 1·81 CI: 1·06-3·08); and in donors aged g50 years compared to ages 16-19 (OR = 6·4 CI: 2·95-13·86). After controlling for age, sex and population group, there was no difference in prevalence between new and repeat blood donors or among geographic regions within South Africa.ConclusionsWe conclude that HTLV-1 infection is widespread among the Black population of South Africa and its epidemiology is similar to other endemic areas. Because South Africa is increasing its recruitment of Black blood donors, the implications for blood screening require further consideration. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0042-9007 1423-0410 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c581e1ce940ab3f5ecf6cea7c07fe4fTest https://hal-pasteur.archives-ouvertes.fr/pasteur-03208040/documentTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c581e1ce940ab3f5ecf6cea7c07fe4f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00429007 14230410 |
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