Prognostic factors for long-term outcomes in acute decompensated heart failure patients under tolvaptan treatment
| العنوان: | Prognostic factors for long-term outcomes in acute decompensated heart failure patients under tolvaptan treatment |
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| المؤلفون: | Ichiro Shiojima, Kazuya Takehana, Kei Yoshioka, Koichiro Matsumura, Shun Morishita, Hiroki Takahashi, Naoki Taniguchi, Munemitsu Otagaki, Masahiko Takagi, Yoshihiro Yamamoto |
| المصدر: | Heart and Vessels. 34:607-615 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Acute decompensated heart failure, Tolvaptan, 030204 cardiovascular system & hematology, Patient Readmission, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, Aged, Heart Failure, Dose-Response Relationship, Drug, Proportional hazards model, business.industry, Incidence (epidemiology), Sodium, Hazard ratio, Stroke Volume, Prognosis, medicine.disease, Confidence interval, Cardiac surgery, Survival Rate, Heart failure, Acute Disease, Female, Cardiology and Cardiovascular Medicine, business, Antidiuretic Hormone Receptor Antagonists, Follow-Up Studies, medicine.drug |
| الوصف: | Inconsistent results have been reported concerning the effect of tolvaptan treatment on long-term prognostic outcomes in patients with acute decompensated heart failure (ADHF) and data are limited on prognostic factors affecting this patient population. We investigated prognostic factors influencing long-term clinical outcomes in patients with ADHF treated with tolvaptan in a real-world setting. A total of 263 consecutive patients hospitalized for ADHF and treated with tolvaptan were retrospectively enrolled. The patients were stratified into those who developed the combined event of cardiac death or rehospitalization for worsening heart failure within 1 year (n = 108) and those who were free of this combined event within 1 year (n = 155). Adjusted multivariate Cox proportional hazards model revealed that change in serum sodium level between pre-treatment and 24 h after tolvaptan administration [hazard ratio (HR) 0.913, 95% confidence interval (CI) 0.841–0.989, p = 0.025] and the time taken for tolvaptan initiation from admission (HR 1.043, 95% CI 1.009–1.074, p = 0.015) were independent predictors of combined event occurrence within 1 year. Moreover, change in serum sodium level > 1 mEq/L between pre-treatment and 24 h after administration and initiation of tolvaptan |
| تدمد: | 1615-2573 0910-8327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba42d3f298e8ab353010c98bd862f3cTest https://doi.org/10.1007/s00380-018-1290-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2ba42d3f298e8ab353010c98bd862f3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16152573 09108327 |
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