Clinicopathologic comparisons of IgA nephropathy and IgA vasculitis nephropathy in children: a ten-year single-center experience
| العنوان: | Clinicopathologic comparisons of IgA nephropathy and IgA vasculitis nephropathy in children: a ten-year single-center experience |
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| المؤلفون: | N A Wang, Yuxue Wang, Yuheng Liang, Zhi-Yan Dou, Bo Yu, Zan-Hua Rong, Xinliang Wang, Qingxiao Su, Xue Zhao |
| المصدر: | Turkish Journal of Medical Sciences |
| بيانات النشر: | The Scientific and Technological Research Council of Turkey, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, IgA Vasculitis, Renal function, anaphylactoid purpura, urologic and male genital diseases, Kidney, Gastroenterology, Article, Nephropathy, chemistry.chemical_compound, children, Internal medicine, medicine, Humans, clinical and pathological features of kidney, Child, Retrospective Studies, Creatinine, Proteinuria, Nephritis, business.industry, IgA vasculitis nephritis, Glomerulonephritis, IGA, General Medicine, IgA nephropathy, medicine.disease, IgA vasculitis, chemistry, Renal pathology, medicine.symptom, business, Nephrotic syndrome |
| الوصف: | Background/aim To investigate the similarities and differences of renal clinical and renal pathology between IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN) in children. Materials and methods A total of 237 children with IgAN and 190 children with IgAVN were included. The general conditions, clinical characteristics, final diagnosis, clinical and pathological classification of the children were intercepted at the time of admission, and the retrospective comparative analysis was carried out. Results The results showed that the median course of disease in IgAN group was longer than that in IgAVN group (p = 0.02). Patients with IgAN had a significantly higher duration of infection than the patients with IgAVN (p = 0.03). The white blood cell count (WBC), hemoglobin (HGB) in IgAN group were significantly lower than that in IgAVN group (p = 0.02). The serum creatinine in IgAN group was higher than that in IgAVN group (p = 0.02). Patients with IgAN and IgAVN had statistically significant differences in pathological typing between clinical types: hematuria and proteinuria, nephrotic syndrome and chronic nephritis (p = 0.004). Conclusion The clinical manifestations of IgAN and IgAVN were similar, but the onset of IgAN was hidden and the clinical manifestations were relatively serious. Renal pathology was mainly glomerulosclerosis and renal tubular atrophy. IgAVN was characterized by acute onset and good renal function. Renal pathology was dominated by endothelial hyperplasia and crescent formation. These differences did not support the hypothesis that the two diseases are the same. |
| اللغة: | English |
| تدمد: | 1303-6165 1300-0144 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7bb7aacf6a44ba3f2a29f0ee295d1bTest http://europepmc.org/articles/PMC8742479Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a7bb7aacf6a44ba3f2a29f0ee295d1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13036165 13000144 |
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