Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients
| العنوان: | Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients |
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| المؤلفون: | Camelia Larisa Vonica, Cerasela Mihaela Goidescu, Roxana Mihaela Chiorescu, Florin Petru Anton, Luminița Animarie Vida-Simiti, Mihaela Mocan, Anca Daniela Farcas, Mocan-Hognogi Larisa Diana, Mirela Anca Stoia |
| المصدر: | Disease Markers Disease Markers, Vol 2020 (2020) |
| بيانات النشر: | Hindawi, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Medicine (General), Article Subject, Clinical Biochemistry, Diastole, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Group A, Group B, 03 medical and health sciences, 0302 clinical medicine, R5-920, Internal medicine, Genetics, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Molecular Biology, Aged, business.industry, Biochemistry (medical), General Medicine, Middle Aged, medicine.disease, Prognosis, Interleukin-1 Receptor-Like 1 Protein, Up-Regulation, medicine.anatomical_structure, Logistic Models, Ventricle, Cardiovascular Diseases, Heart failure, Hypertension, Cardiology, Biomarker (medicine), Observational study, Female, business, Biomarkers, Research Article |
| الوصف: | Background. sST2 represents a useful biomarker for the diagnosis and prognosis of patients with heart failure, but limited data is available on its role in patients with hypertension. The aim of this study is to evaluate the short-term prognosis value of sST2 for an unfavorable outcome in hypertensive patients.Methods. This was a prospective observational study which enrolled 80 patients with hypertension, who were followed for one year. All patients underwent clinical, laboratory (including sST2), and echocardiographic assessment at baseline. The patients were grouped according to the cardiovascular (CV) events reported during the follow-up: group A (with CV events) and group B (without CV events).Results. Overall, 59 CV events were reported during the follow-up period. Compared to group B, the patients in group A had significantly higher sST2 levels, a higher number of CV risk factors, and a higher left ventricle mass. Except for the diastolic dysfunction parameters, the echocardiographic findings were similar in the two groups. Patients in group A had a lowerE/Aratio, larger deceleration time, and increased telediastolic pressure as quantified by theE/E′ratio than those in group B. Multivariate logistic regression analysis showed that sST2 and fasting plasma glucose at baseline were independent predictors for the CV events reported during the follow-up period.sST2 levels>28.5 ng/mLwere associated with poor clinical outcomes (p=0.006, Kaplan-Meier analysis).Conclusions. sST2 levels were correlated with the risk of adverse CV outcomes in hypertensive patients and may represent a useful prognostic marker in these patients. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1875-8630 0278-0240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70bf495610179d2d38566c9a6703f0Test http://europepmc.org/articles/PMC7026724Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a70bf495610179d2d38566c9a6703f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758630 02780240 |
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