Reduction Mechanisms of Anticancer Osmium(VI) Complexes Revealed by Atomic Telemetry and Theoretical Calculations
| العنوان: | Reduction Mechanisms of Anticancer Osmium(VI) Complexes Revealed by Atomic Telemetry and Theoretical Calculations |
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| المؤلفون: | Jakub Szlachetko, Gilles Berger, Jacinto Sá, Anna Wach |
| المصدر: | Inorganic chemistry, 60 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | inorganic chemicals, Reducing agent, chemistry.chemical_element, Antineoplastic Agents, Chimie inorganique, 010402 general chemistry, Photochemistry, 01 natural sciences, Chemical reaction, Inorganic Chemistry, Reduction (complexity), Metal, Physico-chimie générale, Coordination Complexes, Osmium, Emission spectrum, Physical and Theoretical Chemistry, Density Functional Theory, Molecular Structure, 010405 organic chemistry, Chemistry, Spectrometry, X-Ray Emission, Chimie théorique, 0104 chemical sciences, Chemical state, visual_art, visual_art.visual_art_medium, Oxidation-Reduction, In situ study |
| الوصف: | Resonant X-ray emission spectroscopy (RXES) has developed in the past decade as a powerful tool to probe the chemical state of a metal center and in situ study chemical reactions. We have used it to monitor spectral changes associated with the reduction of osmium(VI) nitrido complexes to the osmium(III) ammine state by the biologically relevant reducing agent, glutathione. RXES difference maps are consistent with the proposed DFT mechanism and the formation of two stable osmium(IV) intermediates, thereby supporting the overall pathway for the reduction of these high-valent anticancer metal complexes for which reduction by thiols within cells may be essential to the antiproliferative activity. SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf |
| تدمد: | 1520-510X 0020-1669 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a64503ddf5ebdc80a63cc39e5176edeTest https://doi.org/10.1021/acs.inorgchem.1c00467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a64503ddf5ebdc80a63cc39e5176ede |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520510X 00201669 |
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