Dermatologic conditions in Down syndrome: A single‐center retrospective chart review
| العنوان: | Dermatologic conditions in Down syndrome: A single‐center retrospective chart review |
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| المؤلفون: | Karen Wiss, Karan Lal, Lindsay McCormack, Leah Belazarian, Jillian F. Rork |
| المصدر: | Pediatric Dermatology. 37:811-816 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Down syndrome, medicine.medical_specialty, Skin Neoplasms, Adolescent, Folliculitis, Dermatology, Skin Diseases, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Psoriasis, Seborrheic dermatitis, medicine, Humans, Hidradenitis suppurativa, Basal cell carcinoma, Child, Retrospective Studies, business.industry, Infant, Newborn, Infant, medicine.disease, Hidradenitis Suppurativa, Child, Preschool, Pediatrics, Perinatology and Child Health, Eczematous dermatitis, Down Syndrome, Skin cancer, business |
| الوصف: | Background Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders. Objective We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists. Methods This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018. Results Folliculitis was the most common diagnosis overall (30.7%), followed by seborrheic dermatitis (26.7%) and hidradenitis suppurativa (22.8%). Eczematous dermatitis, alopecia areata, and xerosis were the most common diagnoses observed in children aged 0-12 years; hidradenitis suppurativa, folliculitis, and seborrheic dermatitis in adolescents aged 13-17 years; and folliculitis, seborrheic dermatitis, and xerosis in adults 18 years and older. Other notable diagnoses present overall included onychomycosis (9.9%) and psoriasis (8.9%). Malignant cutaneous tumors were present in two patients, specifically basal cell carcinoma and malignant melanoma in situ. Limitations This was a retrospective, single-institution study. Conclusion Dermatologic conditions in patients with Down syndrome vary by age but are most often adnexal and eczematous disorders. Trisomy of chromosome 21 and the resulting downstream effects, specifically on the immune system, may account for these findings. |
| تدمد: | 1525-1470 0736-8046 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f708e772f351c635881be30736b271Test https://doi.org/10.1111/pde.14214Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....29f708e772f351c635881be30736b271 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251470 07368046 |
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