Persistent KSHV infection increases EBV-associated tumor formation In vivo via enhanced EBV lytic gene expression
| العنوان: | Persistent KSHV infection increases EBV-associated tumor formation In vivo via enhanced EBV lytic gene expression |
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| المؤلفون: | Patrick C. Rämer, Mário Henrique M. Barros, Thomas F. Schulz, Michael Spohn, Adam Grundhoff, Adeola Fowotade, Vanessa Landtwing, Robert E. White, Gerald Niedobitek, Ana Raykova, Jaap M. Middeldorp, Martin J. Allday, Riccarda Capaul, Jin-Man Kim, Christine T. Styles, Anita Murer, Alexandra Papoudou-Bai, Isaak Quast, Nicole Caduff, David J. Blackbourn, Donal McHugh, Henri Jacques Delecluse, Christian Münz, Ethel Cesarman, Yong Moon Lee, Andrea Zbinden |
| المساهمون: | CCA - Cancer biology and immunology, AII - Infectious diseases, Pathology, University of Zurich, Münz, Christian |
| المصدر: | 73.e7 Cell host & microbe, 22(1), 61-73.e7. Cell Press McHugh, D, Caduff, N, Barros, M H M, Rämer, P C, Raykova, A, Murer, A, Landtwing, V, Quast, I, Styles, C T, Spohn, M, Fowotade, A, Delecluse, H-J, Papoudou-Bai, A, Lee, Y-M, Kim, J-M, Middeldorp, J, Schulz, T F, Cesarman, E, Zbinden, A, Capaul, R, White, R E, Allday, M J, Niedobitek, G, Blackbourn, D J, Grundhoff, A & Münz, C 2017, ' Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression ', Cell host & microbe, vol. 22, no. 1, pp. 61-73.e7 . https://doi.org/10.1016/j.chom.2017.06.009Test |
| بيانات النشر: | Cell Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, 10028 Institute of Medical Virology, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Genes, Viral, viruses, 2405 Parasitology, PROTEIN, medicine.disease_cause, 10263 Institute of Experimental Immunology, Virus Replication, Mice, 0302 clinical medicine, 1108 Medical Microbiology, hemic and lymphatic diseases, Neoplasms, EPSTEIN-BARR-VIRUS, B-Lymphocytes, Coinfection, 2404 Microbiology, virus diseases, High-Throughput Nucleotide Sequencing, Herpesviridae Infections, 3. Good health, LYMPHOPROLIFERATIVE DISEASE, Survival Rate, Lytic cycle, 030220 oncology & carcinogenesis, B-CELLS, Herpesvirus 8, Human, Cytokines, Primary effusion lymphoma, Life Sciences & Biomedicine, 0605 Microbiology, Gene Expression Regulation, Viral, humanized mouse model, lytic EBV replication, Immunology, Lymphoproliferative disorders, 610 Medicine & health, CELL-LINES, KSHV, Biology, Kaposi sarcoma-associated herpesvirus, Microbiology, Virus, 03 medical and health sciences, HODGKIN-LYMPHOMA, EBV, Virology, Cell Line, Tumor, Lymphoma, Primary Effusion, medicine, Epstein-Barr virus, Animals, Humans, Epstein–Barr virus infection, PRIMARY EFFUSION LYMPHOMA, BURKITTS-LYMPHOMA, Science & Technology, biochemical phenomena, metabolism, and nutrition, virus-associated lymphoma, medicine.disease, Epstein–Barr virus, DNA-SEQUENCES, B cell lymphoma, Disease Models, Animal, 030104 developmental biology, Viral replication, DNA, Viral, 2406 Virology, LATENT, 570 Life sciences, biology, Parasitology, Carcinogenesis, Spleen |
| الوصف: | The human tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) establish persistent infections in B cells. KSHV is linked to primary effusion lymphoma (PEL), and 90% of PELs also contain EBV. Studies on persistent KSHV infection in vivo and the role of EBV co-infection in PEL development have been hampered by the absence of small animal models. We developed mice reconstituted with human immune system components as a model for KSHV infection and find that EBV/KSHV dual infection enhanced KSHV persistence and tumorigenesis. Dual-infected cells displayed a plasma cell-like gene expression pattern similar to PELs. KSHV persisted in EBV-transformed B cells and was associated with lytic EBV gene expression, resulting in increased tumor formation. Evidence of elevated lytic EBV replication was also found in EBV/KSHV dually infected lymphoproliferative disorders in humans. Our data suggest that KSHV augments EBV-associated tumorigenesis via stimulation of lytic EBV replication. |
| وصف الملف: | text |
| اللغة: | English |
| تدمد: | 1931-3128 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294141d37f249da876c755ff877298bdTest http://hdl.handle.net/10044/1/51663Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....294141d37f249da876c755ff877298bd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19313128 |
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