Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus
| العنوان: | Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus |
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| المؤلفون: | Robert Kopajtich, Christian Preisinger, Francis A. Barr, Roman Körner |
| المصدر: | The Journal of Cell Biology |
| بيانات النشر: | The Rockefeller University Press, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Nucleocytoplasmic Transport Proteins, Endosome, Golgi Apparatus, Golgi reassembly, Biology, Autoantigens, Antibodies, symbols.namesake, Report, Two-Hybrid System Techniques, Yeasts, Organelle, Animals, Secretory pathway, Golgi Matrix Proteins, Membrane Proteins, Cell Biology, Golgi apparatus, Transforming Growth Factor alpha, GRASPs, p24 proteins, Golgi matrix, protein transport, cargo receptors, Cell biology, Transport protein, Protein Transport, Membrane protein, Cytoplasm, symbols, Rabbits, Protein Binding |
| الوصف: | The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. This structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil proteins, the golgins, and other peripheral membrane components such as GRASP55 and GRASP65. Here we find that TMP21, p24a, and gp25L, members of the p24 cargo receptor family, are present in complexes with GRASP55 and GRASP65 in vivo. GRASPs interact directly with the cytoplasmic domains of specific p24 cargo receptors depending on their oligomeric state, and mutation of the GRASP binding site in the cytoplasmic tail of one of these, p24a, results in it being transported to the cell surface. These results suggest that one function of the Golgi matrix is to aid efficient retention or sequestration of p24 cargo receptors and other membrane proteins in the Golgi apparatus. |
| اللغة: | English |
| تدمد: | 1540-8140 0021-9525 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28519bfbbf67c04c4b2f98cdd29e91f5Test http://europepmc.org/articles/PMC2150891Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....28519bfbbf67c04c4b2f98cdd29e91f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408140 00219525 |
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